A mechanism of action of a plant ingredient betulin on restoring the suppression of antitumor activity of immune cells by TGF-beta or PGE2.
Project/Area Number |
24590109
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Toyama Prefectural Institute. for Pharmaceutical Research. |
Principal Investigator |
OGASAWARA MASARU 富山県薬事研究所, その他部局等, 研究員 (30443427)
|
Co-Investigator(Renkei-kenkyūsha) |
NAGAI Yoshinori 富山大学, 大学院医学薬学研究部(医学), 准教授 (30431761)
MIYAMOTO Tomomi 富山県薬事研究所, 主任研究員 (20443426)
YAMASAKI Shimno 富山県薬事研究所, 研究員 (50602182)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ベツリン / 腫瘍 |
Outline of Final Research Achievements |
TGF-βand PGE2 secreted by tumor cells strongly inhibit anti-tumor activity of immune cells, which greatly attenuates the effects of tumor therapy, especially cancer immunotherapy. In this study, we focused on the restoring effects of a plant ingredient betulin on the immunosuppression by TGF-βor PGE2, and conducted an analysis of its mechanism of action. It is suggested that betulin restores the suppressive activity of TGF-βor PGE2 through greatly promoting the effects of immune stimulators.
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Report
(4 results)
Research Products
(5 results)