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Regulatory mechanism of diverse G protein signaling in cortical development

Research Project

Project/Area Number 24590113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionAomori University (2014)
Nara Institute of Science and Technology (2012-2013)

Principal Investigator

MIZUNO Norikazu  青森大学, 薬学部, 教授 (90212232)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsシグナル伝達 / 神経科学 / 脳・神経 / 薬学
Outline of Final Research Achievements

To analyze the regulatory mechanisms of diverse G protein signaling in cortical development, (1) we investigated the function of Ric-8A/B, which are novel non-receptor type G protein regulators, in neural stem cells. We found that Ric-8A/B was related to the neural stem cell proliferation, and more, Ric-8B was involved in the facilitatory effect of Gs signaling on the cell migration. (2) We generated the functional antibodies against human GPR56, which inhibited the glioma cell migration. These antibodies revealed that human GPR56 inhibited the cell migration through Gq/Rho pathways.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Agonistic Antibodies Reveal the Function of GPR56 in Human Glioma U87-MG Cells2015

    • Author(s)
      Ohta S, Sakaguchi S, Kobayashi Y, Mizuno N, Tago K, Itoh H.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 4 Pages: 594-600

    • DOI

      10.1248/bpb.b14-00752

    • NAID

      130005062265

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: Involvement of Ric-8B in Gs suppression by Gq signal2013

    • Author(s)
      Riris Jenie, Motoki Nishimura, Mika Fujino, Michio Nakaya, Norikazu Mizuno, Kenji Tago, Hitoshi Kurose & Hiroshi Itoh.
    • Journal Title

      Genes to Cells

      Volume: 18 Issue: 12 Pages: 1095-1106

    • DOI

      10.1111/gtc.12099

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR562013

    • Author(s)
      Saito Y., Kaneda K., Suekane A., Ichihara E., Nakahata S., Yamakawa N., Nagai K., Mizuno N., Kogawa K., Miura I., Itoh H., and Morishita K..
    • Journal Title

      Leukemia

      Volume: 27 Issue: 8 Pages: 1637-1649

    • DOI

      10.1038/leu.2013.75

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of doublecortin by protein kinase A orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration2012

    • Author(s)
      Toriyama M, Mizuno N, Fukami T, Iguchi T, Toriyama M, Tago K, Itoh H
    • Journal Title

      J. Biol Chem

      Volume: 287 Issue: 16 Pages: 12691-12702

    • DOI

      10.1074/jbc.m111.316307

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 機能抗体を用いた癌細胞におけるGPR56の機能解析2014

    • Author(s)
      水野憲一、太田茂之、小林祐希、坂口さやか、伊東 広
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-10 – 2014-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 心筋細胞でのGqシグナルによるGs抑制機構に対するRic-8Bの関与2013

    • Author(s)
      水野 憲一, Riris Istighfari Jenie, 仲矢 道雄,  多胡 憲治, 黒瀬 等, 伊東 広
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 神経細胞の分化に伴うGPR56の発現パターンの変化2013

    • Author(s)
      野島 悠佑, 水野 憲一, 伊東 広
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] LGR5の発現とシグナル伝達の解析2013

    • Author(s)
      根岩 直希, 水野 憲一, 小林 哲夫, 伊藤 友里, 伊東 広
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Remarks] 分子情報薬理学 (伊東研究室)

    • URL

      http://bsw3.naist.jp/itoh/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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