| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is known that ketogenic diet treatment is effective for patients with drug-resistant epilepsy. In this study, we focused on metabolic changes induced by ketogenic diets (increases in ketone bodies and decreases in glucose), examined the antiepileptic mechanisms, and explored the mechanism-based antiepileptic compounds. By changing the chemical structure of a ketone body, we found a compound that suppresses excitatory synaptic transmission and epileptiform discharges in vivo. We also found a new mechanism of neural inhibition and antiepileptic action induced by ketogenic diets, and identified the mechanism-based antiepileptic compound.
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