| Project/Area Number |
24590117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YANAGAWA Yoshiki 北海道医療大学, 薬学部, 准教授 (20322852)
MATSUMOTO Machiko 北海道医療大学, 薬学部, 助教授 (70229574)
HIRAIDE Sachiko 北海道医療大学, 薬学部, 助教 (50709277)
SHIKANAI Hiroki 北海道医療大学, 薬学部, 助教 (00632556)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 恐怖行動 / 皮質辺縁系 / 扁桃体 / 発達期ストレス / セロトニン / シナプス可塑性 / サイトカイン / 心的外傷後ストレス障害 / 恐怖記憶 / 情動行動 / 皮質-辺縁系 |
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| Outline of Final Research Achievements |
We reported the persistent influence of early life stress on fear memory regulation, focusing on fear-related behavior and synaptic responses in rats. Aversive stimulus, foot shock (FS), at early postnatal period (before and after weaning) produced behavioral, neurological and electrophysiological changes with the developmental period in adult rats. Sex-difference in fear-related responses was noted in the cortico-limbic area, accompanied with serotonergic dysfunction. We also reported a novel immuno-neurological mechanism in stress-induced fear memory changes. These findings may indicate that traumatic events in early life are implicated in an increased risk of psychiatric diseases, such as depression and anxiety disorders, and provide an idea that normalization of cortico-limbic function has therapeutic potentials for stress-induced emotional disturbance.
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