Elucidation of mechanisms for regulating retinal circulation and identification of target molecule for novel preventive and/or therapeutic drugs for retinopathy
| Project/Area Number |
24590122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
ISHII Kunio 北里大学, 薬学部, 教授 (90137993)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAHARA Tsutomu 北里大学, 薬学部, 准教授 (10296519)
MORI Asami 北里大学, 薬学部, 助教 (80453504)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 薬理学 / 微小循環 / 糖尿病 / 血管生物学 / 網膜 / 血管内皮 / 一酸化窒素 / 網膜循環 / β アドレナリン受容体 |
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| Outline of Final Research Achievements |
This study demonstrated that nitric oxide (NO)-induced vasodilator response is mediated via cycloocygenase/prostaglandin I2/prostanoid IP/cAMP signaling pathway and voltage-dependent potassium channel in rat retinal arterioles. Moreover, our results suggested that the activation of large-conductance calcium-activated potassium (BKCa) channels is involved in stimulation of beta2-adrenoceptor-mediated vasodilation of rat retinal arterioles. Increased oxidative stress may contribute to attenuate retinal vasodilator responses induced by an activator of BKCa channels in diabetic rats. Furthermore, the dysfunction of retinal arterioles in diabetic rats tended to be suppressed by administration of an antioxidant drug. In conclusion, drugs that improve retinal circulation and possess antioxidative effect are considered to be novel candidates for prevention of retinopathy.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Activation of the TRPV1 channel attenuates N-methyl-d-aspartic acid-induced neuronal injury in the rat retina.2014
Author(s)
Sakamoto K, Kuroki T, Okuno Y, Sekiya H, Watanabe A, Sagawa T, Ito H, Mizuta A, Mori A, Nakahara T, Ishii K.
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Journal Title
Eur J Pharmacol.
Volume: 733
Pages: 13-22
DOI
Related Report
Peer Reviewed / Open Access
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