Abnormal LPA receptor signaling in cancer

• Project/Area Number: 24590129
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kinki University
• Principal Investigator: FUKUSHIMA Nobuyuki 近畿大学, 理工学部, 准教授 (10254161)
• Co-Investigator(Renkei-kenkyūsha): TSUJIUCHI Toshifumi 近畿大学, 理工学部, 教授 (10254492)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: リゾホスファチジン酸 / がん / 変異体 / 脂肪酸 / 卵巣がん細胞 / 受容体 / がん細胞

Outline of Final Research Achievements

Lysophosphatidic acid (LPA) is a lysolipid mediator that exerts various physiological actions. The effects of LPA are mediated through at least six types of LPA receptors, including LPA1~LPA6. Involvement of LPA receptor-mediated signaling in cancer growth has been so far suggested. The present study demonstrated that LPA receptor mutants observed in cancer tissues showed abnormal cellular distribution and intracellular signaling. Further analysis for LPA signaling in a certain type of ovarian cancer cell line revealed that the effects of LPA signaling were partly attributed to a fatty acid liberated from LPA.

Research Products

• [Journal Article] Lysophosphatidic acid receptors in cancer pathobiology. (2014)
  • Author(s): Tsujiuchi T, Araki M, Hirane M, Dong Y, Fukushima N.
  • Journal Title: Histol Histopathol. Volume: 29 Pages: 313-321
  • Peer Reviewed
• [Journal Article] Diverse effects of LPA receptors on cell motile activities of cancer cells. (2014)
  • Author(s): Tsujiuchi, T., Hirane, M., Dong, Y. and Fukushima N.
  • Journal Title: J Recept Signal Transduct Res. Volume: 34 Issue: 3 Pages: 149-153
  • DOI: 10.3109/10799893.2013.876042
  • Peer Reviewed
• [Journal Article] Extracellular lipid metabolism influences the survival of (2013)
  • Author(s): Kuwata S, Ohkubo K, Kumamoto S, Yamaguchi N, Izuka N, Murota K, Tsujiuchi T,
  • Journal Title: Biochem Biophys Res Commun Volume: 439 Issue: 2 Pages: 280-284
  • DOI: 10.1016/j.bbrc.2013.08.041
  • Peer Reviewed
• [Presentation] 多価不飽和脂肪酸は活性酸素産生とMAPキナーゼ経路活性化を介して卵巣がん細胞死を引き起こす (2014)
  • Author(s): 福嶋伸之、田中亞以子、辻内俊文、岩森正男
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館（京都府、京都市）
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 脂肪酸によるがん細胞成長の調節 (2014)
  • Author(s): 福嶋伸之
  • Organizer: 第56回日本脂質生化学会
  • Place of Presentation: 近畿大学（大阪府、東大阪）
  • Year and Date: 2014-06-06 – 2014-06-07
  • Invited
• [Presentation] LPA1の変異は小胞体への蓄積と情報伝達の異常を生じる (2013)
  • Author(s): 石井章一、辻内俊文、福嶋伸之
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] 脂肪酸による卵巣がん細胞HNOAの細胞死抑制機構 (2013)
  • Author(s): 福嶋伸之、辻内俊文、岩森正男
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] ラットがん組織から見出されたLPA1変異体の機能解析 (2012)
  • Author(s): 石井 章一, 辻内 俊文, 福嶋 伸之
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場（福岡県）
• [Book] Lysophospholipid Receptors (2013)
  • Author(s): Fukushima, N.
  • Publisher: Wiley
• [Remarks]
  • URL: http://www.life.kindai.ac.jp/~nfukushima/Welcome.html