Research on the apelin as a therapeutic target molecule in ischemic retinopathy using genetically modified animals
| Project/Area Number |
24590131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIOKA Yasuhiro 摂南大学, 薬学部, 講師 (40330360)
YAMAMURO Akiko 摂南大学, 薬学部, 助手 (20340862)
ISHIMARU Yuki 摂南大学, 薬学部, 助教 (80611607)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | アペリン / 虚血性網膜症 / 網膜血管新生 / 血管成熟化 / MCP-1 / 血管壁細胞 / フィブロネクチン / apelin |
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| Outline of Final Research Achievements |
Ischemic retinopathy such as proliferative diabetic retinopathy causes blindness through the hemorrhage in immature vessels formed by the progression of the diseases. Therefore, there is a need to identify mechanisms of vascular maturation, which is the stage of mural cell adhesion to endothelial cells for stabilization of blood vessels, for the treatment of ischemic retinopathy. In this study, we revealed that inhibition of apelin expression induced the vessel maturation in the retina of an ischemic retinopathy model mouse. Moreover, we demonstrated that apelin blockade in cultured-endothelial cells led to increase of monocyte chemoattractant protein-1 (MCP-1) which is a mural cell recruitment factor.
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Report
(4 results)
Research Products
(10 results)
