Functional analysis of regulatory roles of chondroitin sulfate chains in neurite outgrowth for neuro-regenerative therapies
| Project/Area Number |
24590132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | コンドロイチン硫酸 / 受容体 / 神経突起伸長 / 細胞外シグナル分子 / シグナル伝達 / 発現制御 / グリコサミノグリカン / 糖鎖 / 細胞内シグナル伝達 / 酵素 |
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| Outline of Final Research Achievements |
Chondroitin sulfate (CS) is a multifunctional molecule that is widely distributed in extracellular spaces. In central nervous system, the pathological features of CS as major axon growth inhibitory molecules have attracted much attention, whereas several CS preparations have profound stimulatory effects on neurite outgrowth. Recently, our group demonstrated the existence of CS receptor molecules for the first time, and established a new concept that CS can act as a dynamic extracellular signaling molecule that trigger intracellular signaling cascades. Therefore, this project was to investigate the molecular mechanisms for the CS-mediated regulation in neurite outgrowth for neuro-regenerative therapies.
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Report
(4 results)
Research Products
(27 results)
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[Book] Glycosaminoglycans: their modes of action for a possible new avenue for therapeutic intervention. in Glycoscience: Biology and Medicine (Taniguchi, N., Endo, T., Hart, G.W., Seeberger, P.H., and Wong, C.H., eds)2014
Author(s)
Mikami T, Kitagawa H
Total Pages
1569
Publisher
Springer, Japan
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