| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
Chondroitin sulfate (CS) is a multifunctional molecule that is widely distributed in extracellular spaces. In central nervous system, the pathological features of CS as major axon growth inhibitory molecules have attracted much attention, whereas several CS preparations have profound stimulatory effects on neurite outgrowth. Recently, our group demonstrated the existence of CS receptor molecules for the first time, and established a new concept that CS can act as a dynamic extracellular signaling molecule that trigger intracellular signaling cascades. Therefore, this project was to investigate the molecular mechanisms for the CS-mediated regulation in neurite outgrowth for neuro-regenerative therapies.
|
