| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Synthetic study of cotylenin A, a natural product which stabilize protein-protein interactions was carried out. A-ring part was synthesized with intramolecular aldol reaction from optically active perillyl alcohol stereoselectively. Furthermore, Construction of 8-membered ring of B-ring part was accomplished by ring closing metathesis reaction via the coupling reaction of A-ring and C-ring and the subsequent functionalizations. Now we are working on stereoselective incorporation of two hydroxyl groups. On the other hand, we are almost finished synthesis of two parts of sugar-moiety. We will assemble these two parts by double acetalization reaction. And we are planning to complete total synthesis of cotylenin A, synthesize derivatives and analyze functions of synthesized compounds.
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