Nnew approch to discover the medicinal seeds using the cross-reactivity of monoclonal antibody
Project/Area Number |
24590139
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | monoclonal antimody / cross-reactivity / ELISA / morphine / polyacetylene / papuamine / haliclonadiamine / monoclonal antibody / cross reactivity / petrosynone / 抗原抗体反応 / 交差反応 / モルヒネ / 海綿 / ビスアセチレン / アルカロイド / 海洋無脊椎動物 |
Outline of Final Research Achievements |
Cross-reactivity is the reaction against a different but similar antigen. We hypotheses that the recognition site of antibody is equivalent to the receptor domain, and utilizing the cross-reactivity, it makes possible to discover the new structures which possess the equivalent of pharmacophar as a small molecule antigen. We developed the new approach for natural product drug discovery utilizing the cross-reactivity of anti-morphine monoclonal antibody (MAb).
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Report
(4 results)
Research Products
(4 results)