Photocontrol of Peptide Function: A Cyclization Strategy
Project/Area Number |
24590142
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | Nagoya City University |
Principal Investigator |
UMEZAWA Naoki 名古屋市立大学, 薬学研究科(研究院), 准教授 (40347422)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 環状ペプチド / 光切断性リンカー / 光応答性 / ケージド化合物 / 光切断性アミノ酸 / ペプチド |
Outline of Final Research Achievements |
Biologically active compounds with light-responsive function offer experimental possibilities that are otherwise difficult to achieve. Temporal and spatial regulation of protein functions is central to biological processes. Hence, the ability to artificially trigger molecular events in a biologically relevant context is expected to be useful for the study of living organisms. Photoactivatable peptides are powerful tools for controlling cellular signaling; we are developing a general principle to design and synthesize these molecules. In this study, the requisite technology, namely, photo-cleavable linkers and efficient methods to synthesize cyclic peptides, have been developed. The utility of photoactivatable peptides is not limited to the basic research; this methodology could also contribute to the development of pharmaceuticals with reduced side effects.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles.2014
Author(s)
Okada K, Hidese R, Fukuda W, Niitsu M, Takao K, Horai Y, Umezawa N, Higuchi T, Oshima T, Yoshikawa Y, Imanaka T, Fujiwara S
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Journal Title
J.Bacteriol.
Volume: 196
Issue: 10
Pages: 1866-1876
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of Helical Conformation and Side-Chain Structure on y-Secretase Inhibition by β-Peptide Foldamers : Insight into Substrate Recognition2013
Author(s)
Yuki Imamura, Naoki Umezawa, Satoko Osawa, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, Tsunehiko Higuchi
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Journal Title
J. Med. Chem.
Volume: 56
Issue: 4
Pages: 1443-1454
DOI
Related Report
Peer Reviewed
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