| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Biologically active compounds with light-responsive function offer experimental possibilities that are otherwise difficult to achieve. Temporal and spatial regulation of protein functions is central to biological processes. Hence, the ability to artificially trigger molecular events in a biologically relevant context is expected to be useful for the study of living organisms. Photoactivatable peptides are powerful tools for controlling cellular signaling; we are developing a general principle to design and synthesize these molecules. In this study, the requisite technology, namely, photo-cleavable linkers and efficient methods to synthesize cyclic peptides, have been developed. The utility of photoactivatable peptides is not limited to the basic research; this methodology could also contribute to the development of pharmaceuticals with reduced side effects.
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