Synthesis of Nucleoside Derivatives Applicable to Nucleic Acid Medicine
Project/Area Number |
24590143
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Drug development chemistry
|
Research Institution | Tohoku Pharmaceutical University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | Nucleoside / aniti-HIV / antiherpes / Nucleic acid medicine / ヌクレオシド / 4'-チオヌクレオシド / グリコシル化反応 / 4-チオ糖 / 抗HIV活性 / スタブジン / nucleoside / nucleotide / antiviral |
Outline of Final Research Achievements |
To develop nucleoside derivatives applicable to introduce an oligonucleotide which can be used as nucleic acid medicine, design and synthesis of new nucleosides were investigated. We designed the following three nucleoside derivatives: 1) dihydropyranonucleoside, 2) L-threopentofuranosyl nucleoside, 3) 3’-deoxy-4’-thionucleoside. L-Threopentofuranosyl nucleoside was further converted to the corresponding nucleoside phosphonate derivative. All the nucleoside derivatives obtained were evaluated their antiviral activity including HIV.
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Report
(4 results)
Research Products
(22 results)