Search for new unti-diabetic medicine from functional foods through the reduction of liver fat
Project/Area Number |
24590153
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | Kinki University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MORIKAWA Toshio 近畿大学, 薬学総合研究所, 准教授 (10340449)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 糖尿病 / 脂肪肝 / 肝臓 / 中性脂肪 / 耐糖能 / Nigella sativa / Camellia sinensis / HepG2 / fatty liver / diabetes / flavonol glycoside / diterpenoid / Shorea roxburghii / Sedum sarmentosum |
Outline of Final Research Achievements |
From a series of search for anti-diabetic compounds from functional foods, several compounds which reduced contents of triglyceride (TG) in hepatocytes were found. Through the period of this study, (-)-hopeaphenol from burk of Shorea roxbughii, sarmenosides from aerial parts of Sedum sarmentosum, nigellamines from seeds of Nigella sativa, and flavonol glycosides from Rosa canina and Camellia sinensis were elucidated as bioactive compounds which reduced TG contents in hepatocytes. Moreover, reduction of liver TG in mice was observed in vivo studies through the oral administration of several extracts.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice.2014
Author(s)
Toshio Morikawa, Kiyofumi Ninomiya, Mio Imamura, Junji Akaki, Shota Fujikura, Yingni Pan, Dan Yuan, Masayuki Yoshikawa, Xiaoguang Jia, Zheng Li, Osamu Muraoka
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Journal Title
J. Nat. Med., 68, 561―566 (2014).
Volume: 68
Issue: 3
Pages: 561-566
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Anti-hyperlipidemic constituents from the bark of Shorea roxburghii2012
Author(s)
Morikawa T., Chaipech S., Matsuda H., Hamao M., Umeda Y., Sato H., Tamura H., Ninomiya K., Yoshikawa M., Pongpiriyadacha Y., Hayakawa T., Muraoka O.
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Journal Title
Journal of Natural Medicines
Volume: 66
Issue: 3
Pages: 516-524
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice2014
Author(s)
Toshio Morikawa, Kiyofumi Ninomiya, Mio Imamura, Junji Akaki, Yingni Pan, Dan Yuan, Masayuki Yoshikawa, Xiaoguang Jia, Zheng Li, Osamu Muraoka
Organizer
International Conference on Food for Health in Niigata 2014 (ICFHN2014)
Place of Presentation
朱鷺メッセ 新潟コンベンションセンター(新潟県)
Year and Date
2014-10-30 – 2014-10-31
Related Report
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[Presentation] Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice2014
Author(s)
Toshio Morikawa, Kiyofumi Ninomiya, Mio Imamura, Junji Akaki, Shota Fujikura, Yingni Pan, Dan Yuan, Masayuki Yoshiukawa, Xiaoguang Jia, Zheng Li, Osamu Muraoka
Organizer
The 27th International Conference on Polyphenols (ICP2014)
Place of Presentation
名古屋大学(愛知県)
Year and Date
2014-09-02 – 2014-09-06
Related Report
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