Analysis of transport mechanism of cadmium and manganese in their target organs
| Project/Area Number |
24590168
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental pharmacy
|
|---|
| Research Institution | Tokushima Bunri University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | カドミウム / マンガン / 輸送 / 腎臓 / 神経 / 消化管 / 中毒学 / 金属 / ZIP8 / ZIP14 / 亜鉛輸送体 / 毒性 |
|---|
| Outline of Final Research Achievements |
The purpose of this study was to clarify the mechanism of Cd and Mn transport in the target organs of their toxicity. To examine Cd transport in the proximal tubule of kidney, we obtained immortalized cells derived from S1, S2, and S3 segments of mouse proximal tubule. We found that different patterns of Cd uptake and excretion among segment-specific proximal tubule epithelial cells.
We demonstrated that not ZIP14 which is inducible by cytokines, might play an important role in the uptake of Mn in neuronal cells. The inflammatory cytokine enhanced the accumulation of Mn to neuronal cells via the increase in Mn uptake and the decrease in Mn excretion. These data suggest that metal transporters might play an important role in accumulation of Mn in the brain of neurodegenerative diseases where the levels of inflammatory cytokine are abnormally elevated.
|
Report
(4 results)
Research Products
(34 results)
-
[Journal Article] Quantum dots induce heat shock-related cytotoxicity at intracellular environment.2014
Author(s)
Migita, S., Moquin, A., Fujishiro, H., Himeno, S., Maysinger, D., Winnik, F. M., Taniguchi, A.
-
Journal Title
In Vitro Cell Dev Biol Anim.
Volume: 50（4）
Issue: 4
Pages: 367-372
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells.2012
Author(s)
Fujishiro, H., Yano, Y., Takada, Y., Tanihara, M., Himeno, S.
-
Journal Title
Metallomics
Volume: 4(7)
Issue: 7
Pages: 700-708
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
