| Project/Area Number |
24590176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
MATSUBARA Kazuo 京都大学, 医学(系)研究科(研究院), 教授 (20127533)
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| Co-Investigator(Kenkyū-buntansha) |
YONEZAWA Atsushi 京都大学, 医学研究科, 講師 (90452341)
FUKUDO Masahide 京都大学, 医学研究科, 助教 (60437233)
OMURA Tomohiro 京都大学, 医学研究科, 助教 (00439035)
NAKAGAWA Shunsaku 京都大学, 医学研究科, その他 (50721916)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | パーキンソン病 / L-dopa / ウエアリング・オフ / COMT遺伝子多型 / エンタカポン / L-ドパ / 薬学 / 薬物動態 / 遺伝子多型 / トランスポータ |
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| Outline of Final Research Achievements |
L-dopa remains the gold standard for treating Parkinson's disease (PD); however, long-term L-dopa treatment is associated with motor adverse effects, particularly wearing-off. Entacapone prevents catechol-O-methyltransferase (COMT) from metabolizing L-dopa into 3-methoxy-4-hydroxy-L-phenylalanine in the periphery and ameliorates wearing-off in patients with PD treated with L-dopa for a prolonged period. In the present study, we examined whether the blood concentration of L-dopa was affected by COMT gene polymorphisms in patients taking L-dopa concomitantly with entacapone.
We demonstrated that entacapone did not change the area under the blood concentration-time curve of L-dopa in PD patient who had a low-activity COMT gene. This result suggests that the blood concentration of L-dopa taken concomitantly with entacapone is affected by the COMT gene polymorphism.
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