Therapeutics for renal failure by regulation of uremic toxin excretion
| Project/Area Number |
24590177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 尿毒素 / 慢性腎臓病 / 急性腎傷害 / ミトコンドリア / トランスポーター / エリスロポイエチン / シスプラチン / 虚血再灌流 / トランスレーショナルリサーチ / 虚血 / メタボローム / 尿毒症 / メタボローム解析 / スタチン |
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| Outline of Final Research Achievements |
In patients with chronic kidney disease(CKD) and acute kidney injury(AKI), the uremic toxins might promote renal damages and anemia by cytotoxicities and repression of the expression of renal uremic toxin transporter SLCO4C1and hematopoietic hormone erythropoietin (Epo) produce in the klidney. We explored the new drugs for kidney disease by screening compounds library with Epo producing cells and kidney derived cells. We identified newly synthesized indole compounds and those compounds improved the renal functions and the kidney pathological scores in two mice AKI models, ischemic repercussion injury-model and cisplatin nephropathy. The indole compounds increased the intra cellular ATP content in kidney derived culture cells. The indole derivatives could be the new therapeutic agents for kidney diseases.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regul ation of GATA32013
Author(s)
Akiyama Y, Kikuchi K, Saigusa D, Suzuki T, Takeuchi Y, Mishima E, Yamamoto Y, Ishida A, Sugawara D, Jinno D, Shima H, Toyohara T, Suzuki C, Souma T, Moriguchi T, Tomioka Y, Ito S, Abe T.
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Journal Title
PLoS One
Volume: 8
Issue: 7
Pages: e66518-e66518
DOI
Related Report
Peer Reviewed
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