| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
We recently identified cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in human several cancer tissues. Since Ct-OATP1B3 mRNA expression characteristics in colon and lung cancer and its clinical significance have yet to be identified, in this study, we sought to identify clinical significance of Ct-OATP1B3 mRNA expression in lung and colon cancer by characterizing its expression profile in two groups of matched-colon tissue pairs (cancer/normal). Our results showed that Ct-OATP1B3 mRNA expression levels was significantly higher in cancer tissues than in normal tissues in colon cancer. Similar results were also obtained from lung cancer tissues. Therefore, we concluded that Ct-OATP1B3 mRNA expression is primarily associated with cancer tissues in colon and lung cancer, and that Ct-OATP1B3 mRNA may become a promising biomarker for colon cancer detection.
|
