Physiological function and clinical application of a new psychosis-related molecule
Project/Area Number |
24590183
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | University of Toyama |
Principal Investigator |
MIYAMOTO YOSHIAKI 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20449101)
|
Co-Investigator(Renkei-kenkyūsha) |
NITTA Atsumi 富山大学, 大学院医学薬学研究部(薬学), 教授 (20275093)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 精神疾患 |
Outline of Final Research Achievements |
A new N-acetyltransferase Shati/Nat8l was identified from the brain of psychosis animal model. Shati/Nat8l is the N-acetylaspartate (NAA) biosynthetic enzyme, and NAA is converted into N-acetylaspartylglutamate, a neurotransmitter for the metabotropic glutamate receptor type 3 (mGluR3). In the present study, we investigated physiological function and clinical application of Shati/Nat8l. Our findings revealed that Shati/Nat8l in the dorsal striatum associated with both sociability and motivation by the indirect regulation of the serotonergic neuronal system. Alternatively, Shati/Nat8l in the nucleus accumbens served in emotion via the mGluR3-mediated inhibition of the dopaminergic neuronal system. Thus, Shati/Nat8l in the brain plays an important role in mental health. Moreover, our observations in human study suggested that the analysis of methylation levels on Shati/Nat8l promoter region in genomic DNA derived from peripheral blood was useful to make a diagnosis of mental disease.
|
Report
(4 results)
Research Products
(60 results)
-
-
[Journal Article] Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice2014
Author(s)
Miyamoto Y., Ishikawa Y., Iegaki N., Sumi K., Fu K., Sato K., Furukawa-Hibi Y., Muramatsu S., Nabeshima T., Uno K., Nitta A.
-
Journal Title
Int. J. Neuropsychopharmacol.
Volume: 17
Issue: 08
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice.2014
Author(s)
Miyamoto, Y., Ishikawa, Y., Iegaki, N., Sumi, K., Fu, K., Sato, K., Furukawa-Hibi, Y., Muramatsu, S., Nabeshima, T., Uno, K., Nitta, A.
-
Journal Title
Int. J. Neuropsychopharmacol.
Volume: 印刷中
Related Report
Peer Reviewed
-
[Journal Article] Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene2013
Author(s)
Seo S, Takayama K, Uno K, Ohi K, Hashimoto R, Nishizawa D, Ikeda K, Ozaki N, Nabeshima T, Miyamoto Y, Nitta A
-
Journal Title
PLoS ONE
Volume: 8(10)
Issue: 10
Pages: e76960-e76960
DOI
Related Report
Peer Reviewed
-
[Journal Article] 薬物依存関連新規分子の生理機能解明について.2013
Author(s)
宮本嘉明, 斎鹿絵里子, 堀悦郎, 家垣典幸, 石川雄大, 鷲見和之, 鍋島俊隆, 村松慎一, 西条寿夫, 宇野恭介, 新田淳美.
-
Journal Title
日本神経精神薬理学雑誌
Volume: 33
Pages: 167-173
NAID
Related Report
Peer Reviewed
-
-
-
-
-
[Presentation] N-Acettyltransferase Shati/Nat8l in the dorsal striatum regulates sociability and motivation via control of the serotonergic neuronal system in mice.2014
Author(s)
Nitta Atsumi, Iegaki Noriyuki, Ishikawa Yudai, Sumi Kazuyuki, Furukawa-Hibi Yoko, Muramatsu Shin-ichi, Nabeshima Toshitaka, Uno Kyosuke, Miyamoto Yoshiaki
Organizer
American College of Neuropsychopharmacology, 53rd Annual Meeting
Place of Presentation
Phoenix, USA
Year and Date
2014-12-07 – 2014-12-11
Related Report
-
-
-
-
-
-
-
[Presentation] Depression-like behaviors were induced by overexpression of Shati/Nat8l, an N-acetyltransferase, in the striatum of mice.2014
Author(s)
Miyamoto Yoshiaki, Iegaki Noriyuki, Sumi Kazuyuki, Ishikawa Yudai, Furuta Tatsuya, Furukawa-Hib Yokoi, Muramatsu Shin-ichi, Nabeshima Toshitaka, Uno Kyosuke, Nitta Atsumi
Organizer
The 29th CINP World Congress of Neuropsycchopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-22 – 2014-06-26
Related Report
-
-
[Presentation] PCLO SNP rs13438494 regulates DA and 5-HT uptake, accompanied with splicing efficiency and dependence-like behaviors in genomic association studies.2014
Author(s)
Uno Kyosuke, Nishizawa Daisuke, Seo Seunghee, Sakai Norio, Ohi Kazutaka, Nabeshima Toshitaka, Hashimoto Ryota, Ozaki Norio, Ikeda Kazutaka, Miyamoto Yoshiaki, Nitta Atsumi
Organizer
The 29th CINP World Congress of Neuropsycchopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-22 – 2014-06-26
Related Report
-
[Presentation] PiccoloのSNPであるrs13438494は遺伝子関連解析において依存性関連疾患と関連がありドパミンおよびセロトニンの取り込みを制御する.2014
Author(s)
宇野恭介, 西澤大輔, 除承姫, 高山佳奈子, 松村祥平, 酒井規雄, 大井一高, 鍋島俊隆, 橋本亮太, 尾崎紀夫 池田和隆, 宮本嘉明, 新田淳美.
Organizer
第87回日本薬理学会年会
Place of Presentation
仙台
Related Report
-
-
-
-
-
[Presentation] The role of shati/nat8l in the addicted mice brain.2013
Author(s)
Nitta, A., Ishikawa, Y., Sumi, K., Iegaki, N., Furukawa-Hibi, Y., Muramatsu, S., Nabeshima, T., Uno, K., Miyamoto, Y.
Organizer
World Congress of Pharmacy and Pharmaceutical Sciences 2013; 73rd International Congress of FIP.
Place of Presentation
Dublin, Ireland
Related Report
-
[Presentation] The relationship between Shati/Nat8l and NAA in various age stage in mice brain.2013
Author(s)
Sumi, K., Uno, K., Iwamoto, R., Nabeshima, T., Furukawa-Hibi, Y., Miyamoto, Y., Nitta, A.
Organizer
Neuroscience 2013
Place of Presentation
San Diego, USA
Related Report
-
[Presentation] Different effects of shati/nat8l-overexpression on the responses to methamphetamine between in of the nuclus accumbens and dorsal striatum in mice.2013
Author(s)
Nitta, A,, Sumi, K., Ishikawa, Y., Iegaki, N., Furukawa-Hibi, Y., Muramatsu, S., Nabeshima, T., Uno, K., Miyamoto, Y.
Organizer
Neuroscience 2013
Place of Presentation
San Diego, USA
Related Report
-
-
[Presentation] セロトニンおよびドパミントランスポーターを過剰発現させたPC12およびHEK293細胞において、PCLOのSNPはモノアミン取り込みを制御する.2013
Author(s)
宇野恭介, 高山佳奈子, 徐承姫, 大井一高, 橋本亮太, 西澤大輔, 池田和隆, 酒井規雄, 鍋島俊隆, 宮本嘉明, 新田淳美.
Organizer
Neuro 2013
Place of Presentation
京都
Related Report
-
-
-
-
-
-
-
-
[Presentation] 精神疾患に関連するPCLO SNP rs13438494の分子生物学的検討.2013
Author(s)
宇野恭介, 徐承姫, 松村祥平, 大井一高, 橋本亮太, 西澤大輔, 池田和隆, 酒井規雄, 鍋島俊隆, 宮本嘉明, 新田淳美.
Organizer
第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会
Place of Presentation
沖縄
Related Report
-
-
[Presentation] Overexpression of shati in the nucleus accumbens affects the abnormal behavior induced by methamphetamine in mice.2012
Author(s)
Nitta, A., Ishikawa, Y., Iegaki, N., Muramatsu, S., Nabeshima, T., Furukawa-Hibi, Y., Uno, K., Miyamoto, Y.
Organizer
The 28th CINP World Congress of Neuropsycchopharmacology
Place of Presentation
Stockholm, Sweden
Related Report
-
-
[Presentation] Involvement of Shati on depression-like behavior in the postpartum period in human and mice.2012
Author(s)
Takaoka, K., Uno, K., Inagaki, R., Nagakura, M., Tamaji, A., Ozaki, N., Miyamoto, Y., Nitta, A.
Organizer
The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry / The 55th Annual Meeting of the Japanese Society for Neurochemistry
Place of Presentation
Kobe, Japan
Related Report
-
[Presentation] The differences of the action of shati between the nucleus accumbens and dorsal striatum on the methamphetamine-indeuced addictive behaviors in mice.2012
Author(s)
Sumi, K., Miyamoto, Y., Ishikawa, Y., Iegaki, N., Muramatsu, S., Hibi, Y., Nabeshima, T., Uno, K., Nitta, A.
Organizer
The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry / The 55th Annual Meeting of the Japanese Society for Neurochemistry
Place of Presentation
Kobe, Japan
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-