Research of Change in Pharmacokinetics Related with Age and/or Physical Function
| Project/Area Number |
24590184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
崔 吉道 金沢大学, 附属病院, 教授 (40262589)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGA YUKIO 金沢大学, 薬学系, 助教 (00467101)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 成長過程 / 薬物代謝 / 腸肝循環 / ボリコナゾール / ミコフェノール酸 / バルプロ酸 / メトトレキサート / 薬物動態 / シクロスポリン / 相互作用 / トランスポーター / 体内動態 |
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| Outline of Final Research Achievements |
In vivo kinetics of voriconazole was found to depend on the age in human and rats. From this research with rats, the high activity of flavin-containing monooxygenase at immature stages contributed to this age-related alteration of voriconazole pharmacokinetics. On the other hand, because the capacity of enterohepatic circulation progress with growth, the drug-drug interaction related to enterohepatic circulation at mature stages is more strongly than at immature stages.
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Report
(6 results)
Research Products
(15 results)
