| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
It is well known that platinum drugs induced severe hypersensitivity reaction (HR) after the repeated administration, and basophil activation was observed in patients with a history of carboplatin induced severe HR. However, the precise mechanism by which carboplatin induces basophil activation. To investigate whether IgE-dependent mechanisms, including the overexpression of FceRI, participate in carboplatin-induced basophil activation, 13 ovarian cancer patients were enrolled: 5 with a history of carboplatin-induced severe HR within the past 2 years, and 8 with no such history. Our results indicated that an IgE-dependent mechanism incorporating FceRI overexpression participates in carboplatin-induced severe HR.
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