| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
An increased potency of the central nervous system (CNS) acting compounds are often observed in the patients with acute renal failure (ARF), even in the case of the compounds mainly undergoing the hepatic drug metabolism. Mechanisms underlying the increased potency are investigated in this study. It was revealed that the hepatic drug metabolism is suppressed with inflammation accompanying with ARF, leading to an increased plasma concentration of the compound. In addition, it was demonstrated that the suppressive neuron function is elevated with ARF. These pharmacokinetic and pharmacodynamic factors are probably involved with the ARF-related increased potency of the CNS acting compounds.
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