Analysis of the drug-induced lung toxicity in relation to transdifferentiation of type II cells into type I cells and epithelial-mesenchymal transition
| Project/Area Number |
24590195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
YUMOTO Ryoko 広島大学, 医歯薬保健学研究院(薬), 講師 (70379915)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKANO Mikihisa 広島大学, 大学院医歯薬保健学研究院, 教授 (20211336)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬学 / 薬剤性肺障害 / 肺胞上皮細胞 / II型ーI型分化転換 / 上皮間葉転換 / TGF-β1 / Ⅱ型ーⅠ型分化転換 / II型‐I型分化転換 / 上皮間葉転移 |
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| Outline of Final Research Achievements |
Transforming growth factor-β1 (TGF-β1) induced epithelial-mesenchymal transition (EMT) in cultured alveolar epithelial cell lines, RLE-6TN cells and A549 cells. Anticancer drugs such as bleomycin and methotrexate also induced EMT-like phenotypical changes in these cell lines. In addition, the involvement of TGF-β1 pathway in the EMT induced by these drugs was suggested. These findings would be helpful for the development of a novel strategy to predict the lung toxicity of drug candidates.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Modulation of P-glycoprotein function and multidrug resistance in cancer cells by Thai plant extracts.2014
Author(s)
Takano, M., Kakizoe, S., Kawami M., Nagai J., Patanasethanont, D., Sripanidkulchai B., Yumoto, R.
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Journal Title
Pharmazie
Volume: 69
Pages: 823-828
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Introduction of a single transport gene ABCA3 directs RLE-6TN to more typeII-like alveolar epithelial cells.2013
Author(s)
Takano, M., Yamamoto, C., Sambuichi K., Oda, K., Nagai, J., Shimamoto, A., Tahara, H. and Yumoto, R.
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Journal Title
Membrane
Volume: 38
Pages: 246-253
Related Report
Peer Reviewed
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[Journal Article] Endocytic Uptake of FITC-albumin by Human Alveolar Epithelial Cell Line A5492012
Author(s)
Yumoto, R., Suzuka, S., Oda, K., Imaoka, H. and Nagai, J. and Takano, M.
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Journal Title
Drug Metabolism and Pharmacokinetics
Volume: 27
Issue: 3
Pages: 336-343
DOI
NAID
ISSN
1347-4367, 1880-0920
Related Report
Peer Reviewed
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