| Project/Area Number |
24590202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science (2013-2014)
Nagoya City University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YUASA Hiroaki 名古屋市立大学, 大学院薬学研究科, 教授 (20191471)
OHTA Kinya 名古屋市立大学, 大学院薬学研究科, 助教 (90448704)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 核酸塩基 / トランスポーター / 促進拡散 / 代謝酵素 / ENBT1 / ガンシクロビル / プリン核酸 / プリン塩基 / de novo |
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| Outline of Final Research Achievements |
The purine salvage pathway plays a major role in the production of nucleotides, relying heavily on the supply of nucleobases and nucleosides from extracellular sources. Although specific transporters have been suggested to be involved in facilitating their transport across the plasma membrane in mammals, those which are responsible for utilization of extracellular nucleobases remain unknown. In this research project、we identified ENBT1 as a facilitative and purine-selective nucleobase transporter that mediates, in cooperation with salvage enzymes, the cellular uptake of extracellular purine nucleobases, a key step in the efficient utilization of nucleobases.
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