Genetic polymorphisms in FADS1 and FADS2 alter desaturase activity in a Japanese population

• Project/Area Number: 24590204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Nigata University of Phermacy and Applied Life Sciences (2013-2014); Chiba Institute of Science (2012)
• Principal Investigator: KUBOTA Takahiro 新潟薬科大学, 薬学部, 教授 (50323580)
• Co-Investigator(Kenkyū-buntansha): UCHIYAMA Kan 東京慈恵会医科大学, 医学部, 講師 (10385297) ; ODAHARA Shun-ichi 東京慈恵会医科大学, 医学部, 助教 (50445673)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: Δ6 desaturase / IBD / Crohn's disease / n-3 PUFA / n-6 PUFA / genetic polymorphism / arachidonate cascade / Japanese / Crohn’s disease / delta 6 desaturase / Genetic polymorphism

Outline of Final Research Achievements

We have studied the genetic analysis of the Δ6 desaturase (FADS2) polymorphisms, alter desaturase activity in Japanese individuals, on the metabolic activity of 3-/6-polyunsaturated fatty acid (PUFA).
In addition, we are comparing the relationship between the dietary PUFA ratio and genetic polymorphisms using an in vivo evaluation method in 53 Inflammatory Bowel Disease Japanese patients.

Research Products

• [Journal Article] アザチオプリン／６-メルカプトプリン代謝に関わる薬物代謝酵素とその遺伝的多型 (2015)
  • Author(s): 久保田隆廣
  • Journal Title: 医薬品相互作用研究会 Volume: 38 Pages: 1-7
• [Journal Article] A prospective study evaluating metabolic capacity of thiopurine and associated adverse reactions in Japanese patients with inflammatory bowel disease(IBD). (2015)
  • Author(s): Odahara S, Uchiyama K, Kubota T, Ito Z, Takami S, Kobayashi H, Saito K, Koido S, Ohkusa T.
  • Journal Title: PLoS One Volume: 10 Issue: 9 Pages: 1-13
  • DOI: 10.1371/journal.pone.0137798
  • Peer Reviewed
• [Journal Article] 特集 IBD 診療に有用なインデックスはこれだ ! 潰瘍性大腸炎の内視鏡スコア． (2014)
  • Author(s): 内山幹，伊藤善翔，斉藤恵介，小田原俊一，荒川廣志，小井戸薫雄，大草敏史．
  • Journal Title: Journal of IBD Research Volume: 8(1) Pages: 13-21
• [Journal Article] The fatty acid profile of the erythrocyte membrane in initial-onset inflammatory bowel disease patients. (2013)
  • Author(s): Uchiyama K, Odahara S, Nakamura M, Koido S, Katahira K, Shiraishi H, Ohkusa T, Fujise K, Tajiri H.
  • Journal Title: Digestive Disease and Sciences Volume: 11 Issue: 5 Pages: 1235-1243
  • DOI: 10.1007/s10620-012-2508-6
  • Peer Reviewed
• [Journal Article] クローン病とn-3系多価不飽和脂肪酸(食事療法)． (2012)
  • Author(s): 内山 幹，中村 眞，小田原俊一，白石弘美，片平洌彦，小井戸薫雄，大草敏史．
  • Journal Title: 臨床栄養 Volume: 120 (6) Pages: 791-797
• [Presentation] Utility of Fatty Acid Profile of Erythrocyte Membrane in Identifying Diagnostic Markers of Crohn's Disease. (2015)
  • Author(s): Z. Ito, K. Uchiyama, S. Takami, S. Koido, S. Odahara, T. Kubota, T. Ohkusa.
  • Organizer: American Journal of GASTROENTEROLOGY
  • Place of Presentation: アメリカ合衆国・ハワイ州
  • Year and Date: 2015-10-07
• [Presentation] 初発炎症性腸疾患患者における赤血球膜脂肪酸プロフィール． (2013)
  • Author(s): 内山 幹，小田原俊一，中村 眞，小井戸薫雄，片平洌彦，白石弘美，大草敏史，田尻久雄．
  • Organizer: 日本消化器病学会総会．
  • Place of Presentation: 鹿児島市.