Gender as a susceptibility factor for drug-induced liver injury
| Project/Area Number |
24590207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 薬剤性肝障害 / 性差 / アセトアミノフェン / 四塩化炭素 / グルタチオン / サイトカイン / エストロゲン / 脂質過酸化 / マウス / CYP2E1 / 自殺基質 / フロセミド / インターロイキン-6 |
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| Outline of Final Research Achievements |
Gender differences in drug-induced liver injury (DILI) were investigated in mice. Male mice were mostly susceptible to DILI, and following common and distinctive features in different models were suggested as susceptibility factors. Rapid recovery of hepatic GSH and the resultant resistance to DILI in females were found in acetaminophen hepatotoxicity. On the other hand, severe lipid peroxidation in males and high expression of IL-6 in females were found in carbon tetrachloride hepatotoxicity along with resistance to DILI in females. These factors with gender differences also can be indicative of determinants for interindividual difference of DILI.
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Report
(4 results)
Research Products
(7 results)
