| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To develop a new biomarker for multiple myeloma (MM), the reactivity of L chain-binding oligosaccharides was determined using serum sample and MM cell lines. L chain-binding oligosaccharides derived from MM patients with complication showed high reactivity with Con A lectin. In MM cell lines, lectin reactivity of L chain-binding oligosaccharides was correlated with that of sugar chain on the cell surface, and sugar transferase GnT-V that is involved in tumor metastasis was expressed in the cell lines. Further, IL-6-dependent expression of sialic acid-binding oligosaccharide on cell surface was observed. These results suggested that L chain-binding oligosaccharides reflects sugar chain on MM cell surface, and can be a candidate as biomarker of MM pathological condition.
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