M-protein binding oligosaccharides as a candidate of biomarker for multiple myeloma
| Project/Area Number |
24590209
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Bunkyo Gakuin University |
|---|
Principal Investigator |
IIJIMA Shiro 文京学院大学, 保健医療技術学部, 教授 (30222798)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HATTORI Yutaka 慶應義塾大学, 薬学部, 教授 (20189575)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 多発性骨髄腫 / Mタンパク / 糖鎖 / バイオマーカー / マンノース / シアル酸 / GnT-V |
|---|
| Outline of Final Research Achievements |
To develop a new biomarker for multiple myeloma (MM), the reactivity of L chain-binding oligosaccharides was determined using serum sample and MM cell lines. L chain-binding oligosaccharides derived from MM patients with complication showed high reactivity with Con A lectin. In MM cell lines, lectin reactivity of L chain-binding oligosaccharides was correlated with that of sugar chain on the cell surface, and sugar transferase GnT-V that is involved in tumor metastasis was expressed in the cell lines. Further, IL-6-dependent expression of sialic acid-binding oligosaccharide on cell surface was observed. These results suggested that L chain-binding oligosaccharides reflects sugar chain on MM cell surface, and can be a candidate as biomarker of MM pathological condition.
|
Report
(4 results)
Research Products
(3 results)
