The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in the Central Nervous System
Project/Area Number |
24590213
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Teikyo University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
DEGUCHI Yoshiharu 帝京大学, 薬学部, 教授 (40254255)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 血液脳関門 / トランスポーター / 有機カチオン / 鎮痛薬 / カチオン / 交換輸送体 / blood-brain barrier / organic cation / carnitne / OCTN2 / siRNA / opioid / transporter / オピオイド |
Outline of Final Research Achievements |
The human blood-brain barrier cells have been shown to retain the proton-coupled organic cation antiporter, which is involved in efficient blood-to-brain transport of oxycodone. Further, tramadol, a weak opioid, was also actively transported into the brain across the blood-brain barrier by the proton-coupled organic cation antiporter. Both apomorphine enantiomers were efficiently transported into the brain with similar kinetic parameters. The proton-coupled organic cation antiporter is mediated efficient brain transport of apomorphine and it should be relevant to the rapid onset of pharmacological action of this rescue drug.
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Report
(4 results)
Research Products
(15 results)