Involvement of prostaglandin E2 in pathogenesis of schizophrenia
| Project/Area Number |
24590219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MOURI Akihiro 名城大学, 薬学部, 助教 (20597851)
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| Co-Investigator(Renkei-kenkyūsha) |
NABESHIMA Toshitaka 名城大学, 薬学部地域医療薬局学講座 (70076751)
OZAKI Norio 名古屋大学, 大学院医学研究科精神医学 (40281480)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 統合失調症 / モデルマウス / プロスタグランジンE2 / 環境要因 / 遺伝要因 / コピー数変異解析 / DISC 1 / モデル動物 / 認知機能 / 神経発達異常 / ドパミン / フェンシクリジン / グルタミン酸トランスポーター |
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| Outline of Final Research Achievements |
We investigated the possibility of prostaglandin E2 (PGE2) as a common molecule associated with vulnerability to schizophrenia. PGE2 levels in whole brain were increased after injection of polyinosinic-polycytidylic acid (polyI:C), exposure to CO2, and separation, which are predisposing environmental factors, neonatally. The mice administered polyI:C or PGE2 neonatally exhibited the impairments of emotion/cognition, and the cortical dopaminergic in adult. PGE2 inhibited the neurite growth in the hippocampal neurons. These behavioral and neuronal impairments were not observed in the EP1 knockout mice. The mice administrated PGE2 neonatally were vulnerable to PCP-induced behaviors. In the copy number variants of PGE2-related genes, duplication at Ptges3 was only observed in one schizophrenic patient. In conclusion, PGE2 would be one of potential common molecule associated with environmental rather than genetic vulnerability to schizophrenia.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Blonanserin ameliorates phencyclidine-induced visual-recognition memory deficits: the complex mechanism of blonanserin action involving D3-5-HT2A and D1-NMDA receptors in the mPFC2015
Author(s)
Hida H, Mouri A, Mori K, Matsumoto Y, Seki T, Taniguchi M, Yamada K, Iwamoto K, Ozaki N, Nabeshima T, Noda Y
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Journal Title
Neuropsychopharmacology
Volume: 40
Issue: 3
Pages: 601-613
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Plasma dehydroepiandrosterone sulfate levels in patients with major depressive disorder correlate with remission during treatment with antidepressants2014
Author(s)
Tokiko Morita, Koji Senzaki, Ryoko Ishihara, Kazunori Umeda, Nakao Iwata, Taku Nagai, Hirotake Hida, Toshitaka Nabeshima, Kazunori Yukawa, Norio Ozaki, Yukihiro Noda
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Journal Title
Hum. Psychopharmacol.: Clin. Exp.
Volume: 29
Issue: 3
Pages: 280-286
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of repeated dosing with mirtazapine, trazodone, or placebo on driving performance and cognitive function in healthy volunteers2013
Author(s)
Kazumi Sasada, Kunihiro Iwamoto, Naoko Kawano, Kunihiro Kohmura, Maeri Yamamoto, Branko Aleksic, Kazutoshi Ebe, Yukihiro Noda, Norio Ozaki
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Journal Title
Human Psychopharmacology: Clinical and Experimental
Volume: 28
Issue: 3
Pages: 281-286
DOI
Related Report
Peer Reviewed
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