Transplantation of bone marrow-derived microglia-like cells for the new cell therapy against Alzheimer's disease
| Project/Area Number |
24590222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Yoshihisa 京都薬科大学, 病態生理学分野, 准教授 (60195295)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 移植・再生医療 / 神経科学 / 痴呆 / トランスレーショナルリサーチ / 脳神経疾患 / アルツハイマー病 / ミクログリア / 骨髄幹細胞 |
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| Outline of Final Research Achievements |
Clearance of amyloid-β (Aβ) from the brains of patients with Alzheimer's disease (AD) has been expected to be a disease-modifying therapy. Microglia are immune cells in the brain and have an ability of Aβ phagocytosis. In this study, we demonstrated that mouse or human bone marrow cells are able to differentiate into microglia-like cells by the stimulation of M-CSF and indicate the ability of Aβ phagocytosis. By the administration of bone marrow cell-derived microglia-like cells into lateral ventricle or tail vain, a part of cells moves to the brain parenchyma. Furthermore, the intra-ventricle injection of the cells decreases brain Aβ level, while the injection from the tail vain does not attenuate the brain Aβ burden and deficit of spatial learning and memory. More efficient delivery of bone marrow-derived microglia-like cells into the brain parenchyma will be the crucial key for the development of the disease-modifying therapy against AD.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Effective internalization of U251-MG-secreted exosomes into cancer cells and characterization of their lipid components2015
Author(s)
Toda, Y., Takata, K., Nakagawa, Y., Kawakami, H., Fujioka, S., Kobayashi, K., Hattori Y., Kitamura, Y., Akaji, K., Ashihara, E.
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 456
Issue: 3
Pages: 768-773
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Microglia as a therapeutic target for Alzheimer's disease2014
Author(s)
Kazuyuki Takata, Yoshihisa Kitamura, Florent Ginhoux and Eishi Ahishira
Organizer
Monthly Neuroscience Seminar in Faculty of Medicine & Health Science, University Putra Malaysia
Place of Presentation
Faculty of Medicine & Health Science, University Putra Malaysia (Serdang, Malaysia)
Year and Date
2014-10-15
Related Report
Invited
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