Novel monitoring system of fluoropyrimidines for personalized therapy based on PK/PD modeling using dihydropyrimidine dehydrogenase activity as a biomarker of predicting efficacy and side-effects.
Project/Area Number |
24590223
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
ITO Yukako 京都薬科大学, 薬学部, 講師 (30278444)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 薬物動態 / 抗がん剤 / PK/PD / DDS / 個別医療 / バイオマーカー / 大腸癌 / 個別化医療 / 大腸がん / 5-FU / 抗癌剤 / PK/PD / 5-FU |
Outline of Final Research Achievements |
For personalized chemotherapy in colorectal cancer (CRC), the relationship between plasma ratio of dihydrouracil (UH2)/uracil (Ura) and pharmacokinetics parameters of 5-FU was investigated to evaluate the usefulness as a surrogate marker of DPD activity in liver. Based on the pharmacokinetic parameters estimated from CRC rats, we developed a pharmacokinetic-pharmacodynamic (PK-PD) model with plasma UH2/Ura ratio for predicting the tumor growth in CRC rats. Before 5-FU treatment, the measurement of UH2/Ura values as a surrogate biomarker of DPD activity in liver could predict tumor growth in CRC rats. Besides, the UH2/Ura ratio in plasma could be useful for the optimized dosage regimen for CRC chemotherapy. These findings would be cost-effective and helpful for personalized anti-cancer treatment
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Semi-physiological pharmacokinetic–pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil, and lymphocyte counts in rats.2014
Author(s)
Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Shota Kuwano, Akiko Baba, Kota Shinohara, Asako Nishimura, Nobuhito Shibata, and Kanji Takada:
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Journal Title
Xenobiotica,
Volume: 44
Issue: 1
Pages: 804-818
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Application of dissolving microneedles to glucose monitoring through dermal interstitial fluid2014
Author(s)
Yukako Ito, Mayu Taniguchi, Asuka Hayashi, Miku Anai, Shinya Morita, Emi Ko, Naoko Yoshimoto, Yasuhiro Yoshi, Shinji Kobuchi, Toshiyuki Sakaeda, Kanji Takada: .
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Journal Title
Biol. Pharm. Bull.
Volume: 37,
Pages: 1776-1781
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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