| Project/Area Number |
24590226
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Mukogawa Women's University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Miyako 武庫川女子大学, 薬学部, 講師 (20369028)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HAZEKAWA Mai 武庫川女子大学, 薬学部, 助教 (10509186)
HARAGUCHI Tamami 武庫川女子大学, 薬学部, 助教 (10550741)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
|---|
| Keywords | 味蕾細胞 / キニーネ / マクロライド / パターン分析 / 膜電位 / 膜電位感受性色素 / 硫酸キニジン / クラリスロマイシン / フルボキサミン / 精神神経疾患薬 / 5-FU / フロースルーセル |
|---|
| Outline of Final Research Achievements |
Cultured taste cell system was developed to evaluate membrane potential -time profile caused by treatment of typical bitterness substance, quinine as an alkaloid, macrolides, and Fluvoxamine. The membrane potential time profiles were monitored for above model substances and its profile was classified. The pattern seemed to be clarified by molecular weight, acidity, and lipophilicity for the targeted substance. The duration of membrane potential suggest after -bitterness of the drug.
|
