Blood-brain barrier function change in the chronic obstructive pulmonary disease and protective effect of the renin-angiotensin system inhibitors

• Project/Area Number: 24590228
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Fukuoka University
• Principal Investigator: TOMINAGA Koji 福岡大学, 薬学部, 准教授 (10509623)
• Co-Investigator(Kenkyū-buntansha): YAMAUCHI Astushi 福岡大学, 薬学部, 准教授 (90341453) ; MATSUMOTO Junichi 福岡大学, 薬学部, 助教 (10550064)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 慢性閉塞性肺疾患 / 血液脳関門 / レニンーアンジオテンシン系 / 副作用 / レニン-アンギオテンシン系 / レニンーアンギオテンシン系 / レニン－アンギオテンシン系

Outline of Final Research Achievements

We examined the change of the blood-brain barrier (BBB) functions and mechanism in the chronic obstructive pulmonary disease (COPD), and BBB protective effect with the renin-angiotensin system inhibiter.As a result, BBB tight junction function decreased in the COPD model mouse, and serum IL-13,MCP-2 level is associated with for this functional decline.　Also, this functional decline was protected by the losartan, angiotensin receptor blocker.

Research Products

• [Presentation] 慢性閉塞性肺疾患モデルマウスにおける血液脳関門機能脆弱化にはアンギオテンシンIIが関与する
  • Author(s): 冨永宏治、田中千亜紀、松本亜佑美、松本純一、山内淳史、二神幸次郎、片岡泰文
  • Organizer: 日本薬学会第13４年会
  • Place of Presentation: 熊本市総合体育館