Influence of the affinities of antibody-drug conjugates for Fc receptors and antigens on pharmacokinetics
| Project/Area Number |
24590229
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | National Institute of Health Sciences |
|---|
Principal Investigator |
Suzuki Takuo 国立医薬品食品衛生研究所, 生物薬品部, 主任研究官 (10415466)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 薬物結合抗体（抗体薬物複合体） / 動態 / 受容体親和性 / 抗原親和性 / FcRn / FcγR / イメージング / 安全性 |
|---|
| Outline of Final Research Achievements |
Since antibody-drug conjugates (ADCs) contain highly cytotoxic small molecules, the regulation of pharmacokinetics (including adequate release of cytotoxic molecules) is important to ensure efficacy and safety of ADCs. ADCs might have different binding properties to FcRn, Fc gamma R, and antigen from those of parental antibodies, and their pharmacokinetics might be different by binding state of compounds. However, the influences of the conjugation of compounds on pharmacokinetics have not been fully elucidated. Therefore, we produced various ADC models, elucidated the influences of the conjugation of compounds on the binding properties to antigens and Fc receptors, and established an imaging method that can analyze the release of compounds.
|
Report
(5 results)
Research Products
(6 results)
