Molecular mechanism of the non-uniform response and reversible differentiation of stem cells
Project/Area Number |
24590232
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General anatomy (including Histology/Embryology)
|
Research Institution | Hiroshima University (2013-2014) The University of Tokyo (2012) |
Principal Investigator |
TAKAHASHI SHUJI 広島大学, 理学(系)研究科(研究院), 特任准教授 (90447318)
|
Co-Investigator(Kenkyū-buntansha) |
ARIIZUMI Takashi 玉川大学, 農学部, 教授 (30286166)
TANAKA Toshiaki 東京工業大学, 生命理工学研究科, 助教 (40263446)
NINOMIYA Hiromasa 東京大学, 総合文化研究科, 学術研究員 (40514237)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | アフリカツメガエル / ネッタイツメガエル / ヒトiPS細胞 / 細胞分化 / 発生生物学 / 幹細胞 |
Outline of Final Research Achievements |
In this study, we screened switch factors for two different endoderm in Xenopus. Using information from DNA array and study of the other model animals, a lot of gene are cloned and tested by overexpression. However, the factors did not identified. We are trying to functional screening. We developed a new induction method from human iPS cell to embryonic endoderm. Using this methods, We are trying to induce pancreatic endoderm.
|
Report
(4 results)
Research Products
(58 results)
-
-
-
-
-
-
-
-
-
[Journal Article] ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression.2013
Author(s)
X.Li, Y.Bian, Y.Takizawa, T.Hashiomoto, N.Kitamura, T.Ikoma, J.Tanaka, Y.Inagaki, M.Komada, and T.Tanaka
-
Journal Title
Molecular Cancer Research
Volume: 11
Pages: 1437-1447
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] Functional analyses of a novel Insulin-like factor2014
Author(s)
Yoshikazu Haramoto, ○Shuji Takahashi, Yasuko Onuma, Yuzuru Ito, Makoto Asashima
Organizer
IABHU International Symposium- Frontiers in Amphibian Biology: Endangered Species Conservation and Genome Editing
Place of Presentation
広島大学理学研究科(広島県東広島市)
Year and Date
20140327-20140328
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Genomics Study of the Spemann-Mangold Organizer: Occupancy of Tissue-Specific cis-Regulatory Modules by Otx2 and TLE/Groucho for Embryonic Head Specification.2014
Author(s)
Yuuri Yasuoka, Yutaka Suzuki, Shuji Takahashi, Haruka Someya, Norihiro Sudou, Yoshikazu Haramoto, Ken Cho, Makoto Asashima, Sumio Sugano, Masanori Taira
Organizer
15th International Xenopus Conference
Place of Presentation
Asilomar (California, USA)
Year and Date
2014-08-24 – 2014-08-30
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 新規インスリン様因子の機能解析2013
Author(s)
原本悦和、高橋秀治、小沼泰子、伊藤弓弦、浅島誠
Organizer
第7回日本ツメガエル研究集会
Place of Presentation
秋吉台国際芸術村(山口)
Year and Date
20130923-20130925
Related Report
-
-
[Presentation] アクチビンと臓器形成2013
Author(s)
有泉高史
Organizer
日本生物教育会 第68回大会
Place of Presentation
玉川大学農学部(東京都)
Year and Date
20130808-20130808
Related Report
-
-
-
-
-
[Presentation] Analysis of the Xenopus laevis J-strain genome by BAC end sequencing, FISH, and RNA-sequence2012
Author(s)
Takahashi S, Toyoda A, Kuroki Y, Uno Y, Izutsu Y, Suzuki A, Michiue T, Ogino H, Ochi H, Tanaka T, Fukui A, Ito Y, Ueno N, Asashima M, Matsuda Y, Taira M, Fujiyama A.
Organizer
14th International Xenopus Conference
Place of Presentation
Club Belambra(Gien Peninsula, France)
Year and Date
20120909-20120913
Related Report
-
-
-
-
[Presentation] Massively parallel regulation of head and non-head genes by Otx2, Lim1 and Gsc underlies the evolution of the head organizer in the chordate.2012
Author(s)
Yuuri Yasuoka, Yutaka Suzuki, Shuji Takahashi, Norihiro Sudou, Yoshikazu Haramoto, Yukiko Tandou, Kaoru Kubokawa, Ken W. Cho, Makoto Asashima, Sumio Sugano, Masanori Taira
Organizer
第45回日本発生生物学会大会
Place of Presentation
神戸国際会議場(神戸)
Year and Date
20120528-20120531
Related Report
-
-
-
[Presentation] What we can do with over 300 billion bases of RNA-seq data: The case of Xenopus laevis genome project.
Author(s)
Taejoon Kwon, Shuji Takahashi, Toshiaki Tanaka, Hideki Noguchi, Atsushi Toyoda, Asao Fujiyama, Yutaka Suzuki, Naoto Ueno, Masanori Taira, John B. Wallingford, Edward M. Marcotte.
Organizer
International Symposium on Genome Science
Place of Presentation
The University of Tokyo, Ito International Research Center(東京)
Related Report
Invited
-
[Presentation] Analysis of the Xenopus laevis J-strain genome by BAC end sequencing, FISH, and RNA-sequence
Author(s)
Shuji Takahashi, Atsushi Toyoda, Yoko Kuroki, Yoshinobu Uno, Hideki Noguchi, Yumi Izutsu, Atsushi Suzuki, Tatsuo Michiue, Hajime Ogino, Hirofumi Ochi, Toshiaki Tanaka et al.
Organizer
International Symposium on Genome Science
Place of Presentation
The University of Tokyo, Ito International Research Center(東京)
Related Report
-
-