APC protein's novel function related to morphogenesis and cell differentiation
| Project/Area Number |
24590234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gifu University |
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Principal Investigator |
SENDA TAKAO 岐阜大学, 医学(系)研究科(研究院), 教授 (10187875)
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| Co-Investigator(Kenkyū-buntansha) |
AZUMA Kagaku 岐阜大学, 大学院医学系研究科, 講師 (20273146)
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| Research Collaborator |
WANG Tuya 岐阜大学, 大学院医学系研究科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | APC / APC1638T / 腸上皮 / 細胞動態 / 骨格 / 歩行異常 / hair cycle / 海馬ニューロン / 微小管 |
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| Outline of Final Research Achievements |
APC (adenomatous polyposis coli) was originally identified as a tumor suppressor protein. In the present study, we investigated phenotypes of the APC1638T mouse, which lacks the C-terminus of APC but retains β-catenin-binding domain thus being free of tumors. Various phenotypes of the APC1638T mouse were revealed. Both length of the small intestine and that from the bottom of an intestinal crypt and the tip of a villus in the APC1638T mouse are longer than that in wild-type one. Velocity of the intestinal epithelial cell movement along the villus in the APC1638T mouse is faster than that in wild-type one. Also, the APC1638T mouse exhibited skeletal disorders (short limbs, kyphosis and mal-calcification), lacking of limb-cooperation in gait, and hair-cycle irregularities.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia2014
Author(s)
Takanori Onouchi, Katsunori Kobayashi, Kazuyoshi Sakai, Atsushi Shimomura, Ron Smits, Chiho Sumi-Ichinose, Masafumi Kurosumi Keizo Takao, Ryuji Nomura, Akiko Iizuka-Kogo, Hidenori Suzuki,Kazunao Kondo, Tetsu Akiyama Tsuyoshi Miyakawa Riccardo Fodde and Takao Senda, Riccardo Fodde, Takao
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Journal Title
Molecular Brain
Volume: 7
Issue: 1
Pages: 21-21
DOI
Related Report
Peer Reviewed / Open Access
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