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The analysis of congenital anomalies of caudal body formation

Research Project

Project/Area Number 24590235
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionWakayama Medical University

Principal Investigator

Suzuki Kentaro  和歌山県立医科大学, 先端医学研究所, 講師 (20404345)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordssirenomelia / 体幹後部形成 / Isl1 / Bmp4 / Bmpシグナル / プロジェニター / マーメイドシンドローム / Bmp / 体幹後部 / 泌尿生殖器 / Sirenomelia
Outline of Final Research Achievements

Mermaid syndrome is a developmental malformation of the caudal body characterized by leg fusion and associated anomalies of pelvic/urogenital organs including bladder, kidney, rectum and external genitalia. Despite the many clinical studies of mermaid syndrome in humans, little is known about the pathogenic developmental mechanisms that cause the complex array of phenotypes observed. Isl1Cre;Bmp4flox/flox conditional mutant mice displayed mermaid-like phenotypes including hindlimb fusion and pelvic/urogenital organ dysgenesis. Genetic lineage analyses indicated that Isl1-expressing cells contribute to both the aPCM (anterior Peri-Cloacal Mesenchyme) and the hindlimb bud. Furthermore, we show Bmp signaling is essential for the aPCM formation.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (16 results)

All 2015 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations2014

    • Author(s)
      Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC, Yamada G.
    • Journal Title

      Cell Death Differ.

      Volume: 21 Issue: 6 Pages: 990-997

    • DOI

      10.1038/cdd.2014.21

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-myocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle.2014

    • Author(s)
      Ipulan LA, Suzuki K, Sakamoto Y, Murashima A, Imai Y, Omori A, Nakagata N, Nishinakamura R, Valasek P and Yamada G.
    • Journal Title

      Endocrinology

      Volume: 155(7) Issue: 7 Pages: 2467-79

    • DOI

      10.1210/en.2014-1008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of the External Genitalia and Their Sexual Dimorphic Regulation in Mice.2014

    • Author(s)
      Ipulan LA, Suzuki K, Matsushita S, Suzuki H, Okazawa M, Jacinto S, Hirai S, Yamada G.
    • Journal Title

      Sex Dev.

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation2013

    • Author(s)
      Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N, Yamada G
    • Journal Title

      Oncogene

      Volume: 32 Issue: 29 Pages: 3477-3482

    • DOI

      10.1038/onc.2012.376

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Islet1 Deletion Causes Kidney Agenesis and Hydroureter Resembling CAKUT.2013

    • Author(s)
      Kaku Y, Ohmori T, Kudo K, Fujimura S, Suzuki K, Evans SM, Kawakami Y,Nishinakamura R
    • Journal Title

      J Am Soc Nephrol.

      Volume: 24(8) Issue: 8 Pages: 1242-1249

    • DOI

      10.1681/asn.2012050528

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of ectodermal beta-catenin during external genitalia formation2013

    • Author(s)
      Ahmad Reza Mazahery, Kentaro Suzuki, Akira Nagafuchi, Masayasu Miyajima, Naomi Nakagata, Richard Behringer, and *Gen Yamada
    • Journal Title

      Congenital Anomalies

      Volume: 53(1) Issue: 1 Pages: 34-41

    • DOI

      10.1111/cga.12001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduced BMP Signaling Results in Hindlimb Fusion with Lethal Pelvic/Urogenital Organ Aplasia: A New Mouse Model of Sirenomelia.2012

    • Author(s)
      Suzuki K
    • Journal Title

      PLoS One

      Volume: 7(9) Issue: 9 Pages: e43453-e43453

    • DOI

      10.1371/journal.pone.0043453

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Hedgehog Signal Induced Modulation of Bone Morphogenetic Proteins Signaling : An Essential Signaling Relay for Urinary Tract Morphogenesis2012

    • Author(s)
      Ryuma Haraguchi, Daisuke Matsumaru, Naomi Nakagata, Shinichi Miyagawa, Kentaro Suzuki, Sohei Kitazawa, Gen Yamada
    • Journal Title

      PLoS One

      Volume: 7(7) Issue: 7 Pages: e42245-e42245

    • DOI

      10.1371/journal.pone.0042245

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 性差因子MafBの性差発現制御機構の解明2015

    • Author(s)
      鈴木堅太郎、松下祥子、鈴木裕子、沼田朋和、日野信次朗、佐藤哲也、高橋智、中尾光善、須山幹太、山田源
    • Organizer
      日本農芸化学学会2015年度大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] アンドロゲンによる外生殖器性差形成メカニズムの解明2014

    • Author(s)
      鈴木堅太郎、沼田朋和、鈴木裕子、Raga Dennis、松下祥子、横山智哉子、濱田理人、高橋智、山田源
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 形態的性差を生み出す分子メカニズムの解明を目指して ~アンドロゲンシグナルの標的遺伝子の探求~2014

    • Author(s)
      鈴木堅太郎、沼田朋和、鈴木裕子、松下祥子、Raga Dennis、横山智哉子、山田源
    • Organizer
      日本アンドロロジー学会第33回学術大会
    • Place of Presentation
      軽井沢プリンスホテルウエスト
    • Year and Date
      2014-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] BMP シグナルは、四肢および泌尿生殖器を含む体幹後部形成に不可欠である2013

    • Author(s)
      鈴木 堅太郎、沼田 朋和、柳田 素子、中潟 直己、原口 竜摩、山田 源
    • Organizer
      第53回日本先天異常学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] 形態的性差を生み出す分子メカニズムの解明を目指して ~アンドロゲンシグナルの標的遺伝子の探求~2013

    • Author(s)
      鈴木堅太郎、沼田朋和、松下祥子、鈴木裕子、横山智哉子、山田源
    • Organizer
      日本アンドロロジー学会第32回学術大会
    • Place of Presentation
      大阪国際会議場(グランキューブ大阪)
    • Related Report
      2013 Research-status Report
  • [Presentation] アンドロゲンによる形態的性差を生み出す分子メカニズムの解明2013

    • Author(s)
      鈴木 堅太郎、沼田 朋和、松下 祥子、鈴木 裕子、横山 智哉子、高橋 智、山田 源
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      明治大学、生田キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia2012

    • Author(s)
      鈴木堅太郎
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡(福岡)
    • Related Report
      2012 Research-status Report
  • [Presentation] アンドロゲンによる形態的性差を生み出す分子メカニズムの解明 ~マウス外生殖器発生をモデルとして~

    • Author(s)
      鈴木堅太郎、沼田朋和、松下祥子、鈴木裕子、横山智哉子、山田源
    • Organizer
      第 4 回テストステロン研究会
    • Place of Presentation
      ホテルマロウド軽井沢
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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