The function of semaphorin in the formation of neural network.
Project/Area Number |
24590236
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 神経発生 / 軸索ガイダンス / 脳神経 / ノックアウトマウス / 高次脳機能 / 脳神経系 / 神経回路 |
Outline of Final Research Achievements |
During embryogenesis, axons reach their specific targets correctly to form the complex neural network found in the mature functional nervous system. Several groups of axon guidance molecules such as semaphorins, ephrins, netrins, and Slits have been reported to repel or attract growing axons that express their cognate receptors. Herein, I report the cloning and characterization of novel semaphorin genes. These semaphorin genes might repel axons of the specific types during development.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] lexinA4-dependent retrograde Semaphorin3A signaling regulates the dendritic localization of GluA2-containing AMPA receptors.2014
Author(s)
1) Yamashita, N., Usui, H., Nakamura, F., Chen, S., Sasaki, Y., Hida, T., Suto, F., Taniguchi, M., Takei, K., Goshima, Y.
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 3424-3424
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Brain Endothelial Cells Control Fertility through Ovarian-Steroid-Dependent Release of Semaphorin 3A.2014
Author(s)
Paolo Giacobini, Jyoti Parkash, Celine Campagne, Andrea Messina, Filippo Casoni, Charlotte Vanacker, Fanny Langlet, Barbara Hobo, Gabriella Cagnoni, Sarah Gallet, Daniele Mazur, Masahiko Taniguchi, Massimiliano Mazzone, Joost Verhaagen, Philippe Ciofi, Sebastien G. Bouret, Luca Tamagnone, Vincent Prevot
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Journal Title
PLOS Biology
Volume: 12
Issue: 3
Pages: e1001808-e1001808
DOI
Related Report
Peer Reviewed
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