Study for clarifying mechanisms of amphibian gastrulation from a new perspective.
| Project/Area Number |
24590240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 初期発生 / 形態形成 / 細胞運動 / 原腸胚 / カルシウムイオン / 細胞骨格 / 両生類 / イモリ / カルシウムイオンチャネル |
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| Outline of Final Research Achievements |
Gastrulation is one of important steps for morphogenesis during multicellular animal embryogenesis. However, little is known about their mechanisms. In this study, we investigated the mechanisms and roles of autonomous cell movements in embryonic cells isolated from amphibian gastrula of Japanese newt. Isolated presumptive ectodermal cells carried out mainly circus movement that is based on plasma membrane blebbing. Isolated presumptive mesodermal and endodermal cells, on the other hand, carried out mainly vermiform movement that is based on elongation of cellular body. Their two types of autonomous cell movements in the isolated gastrula cells are regulated by different systems of intracellular calcium signaling and cytoskeleton reassembly. These findings suggest that development and formation of calcium signaling mechanisms depending on a type of germinal layers play an important role in the initiation and execution of morphogenetic cell movements during gastrulation.
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Report
(5 results)
Research Products
(15 results)
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[Presentation] A case of Duplicated Inferior Vena Cava.2015
Author(s)
Hiroyuki Suzuki, Satoko Sutou, Shun Sugimoto, Ryota Suga, Tomohiro Kurisaki, Hidekazu Aochi, Kazuhiro Takano, Keiko Fujita, Masabumi Nagashima
Organizer
第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
Place of Presentation
神戸国際会議場・展示場（兵庫県・神戸市）
Year and Date
2015-03-21 – 2015-03-23
Related Report
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