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Morphological analysis of afferent neurons of galanin-like peptide (GALP) using transgenic mice expressing retrogradely transpoted tracer under the control of GALP promoter with Cre-loxP system.

Research Project

Project/Area Number 24590241
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionKiryu University

Principal Investigator

KAGEYAMA Haruaki  桐生大学, その他部局等, 准教授 (00433839)

Co-Investigator(Kenkyū-buntansha) SHIODA Seiji  昭和大学, 医学部, 教授 (80102375)
Research Collaborator HASEGAWA Fumio  昭和大学, 医学部
HIROSE Sachi  昭和大学, 医学部
ITO Kazuo  昭和大学, 医学部
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords神経回路網 / 遺伝子改変動物 / 摂食調節 / ニューロンネットワーク / 求心性ニューロン / Cre-loxPシステム / 多重免疫染色 / ガラニン様ペプチド / 免疫染色
Outline of Final Research Achievements

Galanin-like peptide (GALP) plays an important role of feeding regulation and energy metabolism. We have reported on neuronal circuits involving GALP in the hypothalamus. To identify afferent neurons of GALP neurons, we used transgenic mice co-expressing retrogradely transpoted tracer and beta-galactosidase under the control of GALP gene regulatory region using Cre-loxP recombination. Afferent neurons are present in the medial septal, medial habenular nucleus, anterodosal thalamic nucleus, medial preoptic nucleus, paraventricular hypothalamic nucleus, hypothalamic arcuate nucleus and Purkinje cells. These results suggest that GALP neurons function as a regulator of not only feeding and energy metabolism but also several physiological actions such as male-typical sexual behavior and reward system.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (41 results)

All 2015 2014 2013 2012

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (25 results)

  • [Journal Article] Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons.2015

    • Author(s)
      Takenoya F, Wang L, Kageyama H, Hirako S, Wada N, Hashimoto H, Ueta Y, Sakagami J, Nonaka, N, Shioda S
    • Journal Title

      J Mol Neurosci

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin suppresses proliferation of fetal neural progenitor cells, and induces their differentiation into neurons.2015

    • Author(s)
      Watanabe J, Matsumoto M, Kageyama H, Murai N, Sasaki S, Hirako S, Wada N, Arata S, Shioda S
    • Journal Title

      Peptides

      Volume: 69 Pages: 40-46

    • DOI

      10.1016/j.peptides.2015.03.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vagal hyperactivity due to ventromedial hypothalamic lesions increases adiponectin production and release.2014

    • Author(s)
      Suzuki Y, Shimizu H, Ishizuka N, Kubota N, Kubota T, Senoo A, Kageyama H, Osaka T, Hirako S, Kim HJ, Matsumoto A, Shioda S, Mori M, Kadowaki T, Inoue S.
    • Journal Title

      Diabetes.

      Volume: 63(5) Issue: 5 Pages: 1637-1648

    • DOI

      10.2337/db13-0636

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 視床下部腹内側核(VMH)破壊によるガストリン産生細胞(G細胞)の細胞増殖を伴わないガストリン産生および分泌亢進2014

    • Author(s)
      吉村英悟、影山晴秋、鈴木洋子、金澤真雄、櫻井純子、瀬野尾 章、石塚典子、荒井勝己、今関信夫、高橋美砂子、佐藤栄子、石井広二、金高有里、橋口剛夫、塩田清二、橋田誠一、井上修二
    • Journal Title

      日本臨床生理学会雑誌

      Volume: 44 Pages: 61-67

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leptin and its receptors.2014

    • Author(s)
      Wada N, Hirako S, Takenoya F, Kageyama H, Okabe M, Shioda S
    • Journal Title

      J Chem Neuroanat

      Volume: 61-62 Pages: 191-199

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vagal hyperactivity due to ventromedial hypothalamic lesions increases adiponectin production and release.2014

    • Author(s)
      Suzuki Y, Shimizu H, Ishizuka N, Kubota N, Kubota T, Senoo A, Kageyama H, Osaka T, Hirako S, Kim HJ, Matsumoto A, Shioda S, Mori M, Kadowaki T, Inoue S.
    • Journal Title

      Diabetes

      Volume: 印刷中

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Galanin-like peptide (GALP) facilitates thermogenesis via synthesis of prostaglandin E2 by astrocytes in the periventricular zone of the third ventricle.2013

    • Author(s)
      Kageyama H, Endo K, Osaka T, Watanabe J, Wang LH, Ito K, Suzuki M, Sakagami J, Takenoya F, Shioda S
    • Journal Title

      J Mol Neurosci.

      Volume: 50(3) Issue: 3 Pages: 443-452

    • DOI

      10.1007/s12031-013-9952-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle.2013

    • Author(s)
      Toda C, Shiuchi T, Kageyama H, Okamoto S, Coutinho EA, Sato T, Okamatsu-Ogura Y, Yokota S, Takagi K, Tang L, Saito K, Shioda S, Minokoshi Y.
    • Journal Title

      Diabetes

      Volume: 62 Issue: 7 Pages: 2295-2307

    • DOI

      10.2337/db12-1629

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interactive effect of galanin-like peptide (GALP) and spontaneous exercise on energy metabolism.2013

    • Author(s)
      Ito K, Kageyama H, Hirako S, Wang L, Takenoya F, Ogawa T, Shioda S
    • Journal Title

      Peptides

      Volume: 49 Pages: 109-116

    • DOI

      10.1016/j.peptides.2013.09.003

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 視床下部腹内側核(VMH)破壊によるガストリン産生細胞(G細胞)の細胞増殖を伴わないガストリン産生および分泌亢進2013

    • Author(s)
      吉村英悟、影山晴秋、鈴木洋子、金澤真雄、瀬野尾 章、石塚典子、荒井勝己、今関信夫、高橋美砂子、佐藤栄子、塩田清二、橋田誠一、井上修二
    • Journal Title

      日本臨床生理学会誌

      Volume: 印刷中

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Galanin-Like Peptide (GALP) Facilitates Thermogenesis via Synthesis of Prostaglandin E(2) by Astrocytes in the Periventricular Zone of the Third Ventricle.2013

    • Author(s)
      Kageyama H
    • Journal Title

      Journal of Molecular Neuroscience

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extracellular Signal-Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle.2013

    • Author(s)
      Toda C
    • Journal Title

      Diabetes

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness States.2013

    • Author(s)
      Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e62391-e62391

    • DOI

      10.1371/journal.pone.0062391

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Morphological analysis of ghrelin neurons in the hypothalamus.2012

    • Author(s)
      Kageyama H, Takenoya F, Shioda S.
    • Journal Title

      Methods Enzymol.

      Volume: 514 Pages: 91-99

    • DOI

      10.1016/b978-0-12-381272-8.00006-4

    • ISBN
      9780123812728
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Shared features of S100B immunohistochemistry and cytochrome oxidase histochemistry in the ventroposterior thalamus and lateral habenula in neonatal rats2012

    • Author(s)
      Muneoka K, Funahashi H, Ogawa T, Whitaker-Azmitia PM, Shioda S.
    • Journal Title

      Int. J. Dev. Neurosci

      Volume: 30 Issue: 6 Pages: 499-505

    • DOI

      10.1016/j.npep.2012.09.007

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuropeptide w.2012

    • Author(s)
      Takenoya Fumiko
    • Journal Title

      Front Endocrinol (Lausanne).

      Volume: 3 Pages: 1-5

    • DOI

      10.3389/fendo.2012.00171

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] GALPによる肝臓の脂質代謝調節機構2015

    • Author(s)
      平子 哲史、竹ノ谷文子、影山晴秋、和田亘弘、塩田清二
    • Organizer
      第120回日本解剖学会・第92回日本生理学会合同大会
    • Place of Presentation
      神戸国際展示場(兵庫県・神戸市)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] ニューロペプチドWのCRHニューロンを介した摂食抑制作用について2015

    • Author(s)
      竹ノ谷文子、平子哲史、和田亘弘、影山晴秋、塩田清二
    • Organizer
      第120回日本解剖学会・第92回日本生理学会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 視床下部腹内側核破壊ラットにおける膵β細胞の増殖機構2015

    • Author(s)
      影山晴秋、石塚典子、鈴木洋子、田中克明、荒井勝己、吉村英悟、今関信夫、瀬野尾 章、小西裕美、白川純、寺内康夫、塩田清二、井上修二
    • Organizer
      第120回日本解剖学会・第92回日本生理学会合同大会
    • Place of Presentation
      神戸国際展示場(兵庫県・神戸市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 摂食調節ペプチドGALP点鼻投与による脂質代謝改善メカニズムの改善2014

    • Author(s)
      平子哲史、竹ノ谷文子、影山晴秋、和田亘弘、木村愛、岡部まい、塩田清二
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県・宮崎市)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 視床下部腹内側核破壊ラットの膵β細胞増殖へのベータトロフィンの関与2014

    • Author(s)
      影山晴秋、鈴木洋子、瀬野尾 章、石塚典子、荒井勝己、今関信夫、関谷果林、吉村英悟、塩田清二、井上修二
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県・宮崎市)
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 視床下部腹内側核破壊ラットの膵β細胞増殖能2014

    • Author(s)
      影山晴秋、石塚典子、鈴木洋子、荒井勝己、吉村英悟、今関信夫、瀬野尾 章、田中克明、塩田清二、井上修二
    • Organizer
      第9回「遺伝子栄養学研究会」学術集会
    • Place of Presentation
      札幌北広島クラッセホテル(北海道・北広島市)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 視床下部腹内側核(VMH)破壊ラットにおける膵β細胞の自己複製2014

    • Author(s)
      石塚典子、影山晴秋、瀬野尾章、鈴木洋子、吉村英悟、荒井勝己、今関信夫、塩田清二、井上修二
    • Organizer
      第28回日本糖尿病・肥満動物学会
    • Place of Presentation
      宮崎・宮崎市民プラザ
    • Related Report
      2013 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)投与による抗肥満作用とその機序2014

    • Author(s)
      平子哲史、影山晴秋、竹ノ谷文子、太田英司、和田亘弘、塩田清二
    • Organizer
      第28回日本糖尿病・肥満動物学会
    • Place of Presentation
      宮崎・宮崎市民プラザ
    • Related Report
      2013 Research-status Report
  • [Presentation] マウスにおけるニューロペプチドW(NPW)の摂食調節作用とストレス関与について2014

    • Author(s)
      竹ノ谷文子、平子哲史、太田英司、和田亘弘、影山晴秋、井上修二、塩田清二
    • Organizer
      第28回日本糖尿病・肥満動物学会
    • Place of Presentation
      宮崎・宮崎市民プラザ
    • Related Report
      2013 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)の神経相関に関する研究2014

    • Author(s)
      太田英司、平子哲史、和田亘弘、竹ノ谷文子、影山晴秋、塩田清二
    • Organizer
      第28回日本糖尿病・肥満動物学会
    • Place of Presentation
      宮崎・宮崎市民プラザ
    • Related Report
      2013 Research-status Report
  • [Presentation] 神経ペプチドWによる室傍核CRHニューロンを介した摂食抑制機構について2014

    • Author(s)
      竹ノ谷文子、平子哲史、太田英司、和田亘弘、影山晴秋、塩田清二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      下野市・自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)による肥満症軽減作用及び作用機序の解明2014

    • Author(s)
      平子哲史、影山晴秋、竹ノ谷文子、太田英司、和田亘弘、塩田清二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      下野市・自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] GALPおよび摂食調節ペプチドの神経相関に関する細胞生理学的検討2014

    • Author(s)
      太田英司、平子哲史、和田亘弘、竹ノ谷文子、影山晴秋、塩田清二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      下野市・自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス自発運動は神経ペプチドWの摂食抑制作用を消失させる2014

    • Author(s)
      和田亘弘、竹ノ谷文子、平子哲史、太田英司、影山晴秋、塩田清二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      下野市・自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 星状膠細胞産生プロスタグランジンE2を介したガラニン様ペプチドの熱産生経路2014

    • Author(s)
      影山晴秋、大坂寿雅、渡邊潤、竹ノ谷文子、平子哲史、 太田英司、井上修二、塩田清二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      下野市・自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)による肝臓脂質代謝改善作用2013

    • Author(s)
      平子哲史、影山晴秋、小川哲郎、竹ノ谷文子、太田英司、和田亘弘、塩田清二
    • Organizer
      第67会日本栄養・食糧学会大会2013
    • Place of Presentation
      名古屋・名古屋大学(東山キャンパス)
    • Related Report
      2013 Research-status Report
  • [Presentation] Neuropeptide W (NPW) modulated of food intake by stress response and voluntary exercise in mouse2013

    • Author(s)
      Takenoya F, Kageyama H, Hirako S, Ota E, Yamamoto N, Ryushi T, Shioda S
    • Organizer
      18th Annual Congress of the European College of Sport Science
    • Place of Presentation
      Institut Nacional d'Educacio Fisica de Catalunya, Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)による脂質代謝改善メカニズムの解明2013

    • Author(s)
      平子哲史、影山晴秋、竹ノ谷文子、太田英司、和田亘弘、塩田清二
    • Organizer
      第45回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京・京王プラザホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)による交感神経を介した肝臓脂質代謝調節作用2013

    • Author(s)
      平子哲史、影山晴秋、竹ノ谷文子、太田英司、和田亘弘、塩田清二
    • Organizer
      第18回アディポサイエンスシンポジウム
    • Place of Presentation
      大阪市・千里ライフサイエンスセンター
    • Related Report
      2013 Research-status Report
  • [Presentation] Analysis of corticotropin-releasing hormone regulation of neuropeptide W in hypothalamic paraventricular nucleus2013

    • Author(s)
      Ota E, Takenoya F, Kageyama H, Hirako S, Wada N, Nonaka N, Ryushi T, Nakamura M, Shioda S
    • Organizer
      36th Naito Conference on Molecular Aspects and Feeding Behavior.
    • Place of Presentation
      札幌市・シャトレーゼ ガトーキングダム サッポロ
    • Related Report
      2013 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)投与による肥満症軽減メカニズムの解明2013

    • Author(s)
      平子哲史、影山晴秋、竹ノ谷文子、太田英司、和田亘弘、塩田清二
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京・東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] NPWによるCRHニューロンを介した摂食抑制の作用機序2013

    • Author(s)
      太田英司、竹ノ谷文子、平子哲史、和田亘弘、影山晴秋、塩田清二
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京・東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] Galanin-like peptide (GALP) ameliorates hepatic lipid metabolism via the sympathetic nervous system2013

    • Author(s)
      Hirako S, Kageyama H, Takenoya F, Ota E, Wada N, Shioda S
    • Organizer
      43rd Annual meeting Society for Neuroscience
    • Place of Presentation
      The San Diego Convention Center, San Diego, California, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Galanin-like peptide (GALP): a key player in the regulation of feeding and energy metabolism2013

    • Author(s)
      Hirako S, Kageyama H, Takenoya F, Ota E, Wada N, Shioda S
    • Organizer
      Galanin SFN pre-meeting 2013
    • Place of Presentation
      The Crowne Plaza San Diego, San Diego, California, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 視床下部腹内側核(VMH)破壊による膵ラ氏島の細胞増殖2013

    • Author(s)
      影山晴秋
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松・かがわ国際会議場(香川県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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