Analysis of gradual steps for a specificity formation of cranial placode by using a novel neural plate explant culture.
| Project/Area Number |
24590244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経板 / 神経板外縁 / 神経堤 / 前プラコード外胚葉 / プラコード / BMP4 / FGF2 / 神経板培養 / ニワトリ胚 / ニワトリ / 胚性外胚葉 |
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| Outline of Final Research Achievements |
A new 'two-step model' has been advocated for the induction of the cranial placode along with the neural crest formation. According to the model, our explanation on the result of the neural plate explant culture should be corrected in part: FGF2 signal possibly has an antagonistic effect on BMP4 signal in our culture system; the induced squamous epithelium has characteristics of an immature composite of the neural border/pre-placodal ectoderm/non-neural ectoderm.
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Report
(5 results)
Research Products
(9 results)
