Maternal-fetal leukemia inhibitory factor signal relay induces aerobic growth and proliferation of fetal cerebral cortex
| Project/Area Number |
24590245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HATTA Toshihisa 金沢医科大学, 医学部, 教授 (20238025)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 発生・分化 / 脳・神経 / 胎盤 / 神経科学 / 細胞・組織 / シグナル伝達 / 増殖因子 / 再生・分化 |
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| Outline of Final Research Achievements |
We have previously reported that maternal leukemia inhibitory factor (LIF) induces adenocorticotropic hormone (ACTH) secretion from the placenta, ACTH stimulates the secretion of fetal LIF from nucleated erythrocytes, and the fetal LIF induces the proliferation of neural stem/progenitor cells (NSC) in the cerebral cortex. In this study, we revealed the downstream network of this maternal-fetal LIF signaling pathway in the fetal cerebrum. The main results are summarized as follows.
1. The secreted fetal LIF induces the secretion of insulin-like growth factors (IGF1 and IGF2), and these IGFs synergistically enhance the action of fibroblast growth factor 2 (FGF2) in NSC proliferation. 2. The placental ACTH promotes the differentiation and enucleation of fetal erythroblasts, and the increased mature erythrocytes elevate the oxygen level in the fetal cerebrum.These results indicate that the LIF pathway enhances fetal brain growth by coordinating NSC proliferation and oxygen supply.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1,2 and 52015
Author(s)
Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
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Journal Title
PLOS ONE
Volume: 10
Issue: 4
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] ラット新生児の定量的人工哺育システムの開発2014
Author(s)
内芝舞実, 島村英理子, 坂田ひろみ, 島田ひろき, 東 伸明, 有川智博, 東海林博樹, 福井義浩, 八田稔久
Organizer
第54回日本先天異常学会学術集会
Place of Presentation
麻布大学（神奈川県 相模原市）
Year and Date
2014-07-26 – 2014-07-27
Related Report
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