| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The unipolar, terminal Schwann cells in the cutaneous sensory devices have a round body and a long process, with the latter branching into glial lamellae. These cells, stellate Schwann-like cells and morphological intermediates between them were examined by immunohistochemistry and electron microscopy of vibrissal lanceolate sensory endings in young rats with special reference to the caveolae and the primary cilium that govern the cell polarity. Purinergically-evoked Ca signals were analyzed in the cells by confocal microscopy. Primary cilia of the stellate cells projected from a central concavity of the nucleus facing the follicular basement membrane, with many caveolae opening into the ciliary pocket. Evoked signals originated from the main body of the cells. Only rudimentary primary cilia occurred at the base of the main process in the intermediate and the unipolar cells, with caveolae accumulated in the lamellae. Ca responses were initiated at individual lamellae in these cells.
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