Fibroblasts and related cells in gastrointestinal tract
| Project/Area Number |
24590250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Fukui |
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Principal Investigator |
IINO SATOSHI 福井大学, 医学部, 教授 (40242854)
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| Co-Investigator(Kenkyū-buntansha) |
HORIGUCHI Kazuhide 福井大学, 医学部, 准教授 (20377451)
HORIGUCHI Satomi 福井大学, 医学部, 学術研究員 (00595283)
HASHIMOTO Takashi 福井大学, 医学部, 特命助教 (60712891)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Shinsuke 名古屋大学, 医学研究科, 准教授 (30192230)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 消化管 / 線維芽細胞 / カハール介在細胞 / 平滑筋細胞 / PDGF受容体α / c-Kit / 消化管神経 / PDGF受容体 / c-kit |
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| Outline of Final Research Achievements |
Fibroblasts and related cells including interstitial cells are thought to have proper functions in each organs. In this study, we analyzed fibroblasts in the murine gastrointestinal (GI) tract. In the GI musculature, there are two types of cells, fibroblasts (fibroblast-like cells) having platelet derived growth factor α receptor (PDGFRα) and SK3 potassium channel, and interstitial cells of Cajal (ICC) having c-Kit tyrosine kinase and TMEM16A. In the GI mucosa, subepithelial fibroblasts (myofibroblasts) showed PDGFRα immunoreactivity and submucosal fibroblasts showed PDGFRα and CD34 immunoreactivities. We also detected Cytoglobin immunoreactivity using newly generated antibody in various fibroblasts in the GI tract.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice.2014
Author(s)
Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H.
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Journal Title
British Journal of Pharmacology
Volume: 171
Issue: 2
Pages: 375-388
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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