Functional analyses of novel candidate genes involved in axonal guidance obtained by comprehensive genetic screening
| Project/Area Number |
24590256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Tsukuba (2013-2014)
Dokkyo Medical University (2012) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATO SHIGEKI 福島県立医科大学, 医学部, 講師 (90443879)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞・組織 / 発生・分化 / 神経科学 / 脳・神経 / 神経・組織 / マイクロアレイ |
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| Outline of Final Research Achievements |
During development, dorsal root ganglion (DRG) neurons extend their axons both centrally and peripherally. However, the molecular mechanism underlying this phenomenon is less clear. By using in-vivo electroporation and adeno-associated virus vectors, we examined the in-vivo functions of 5 candidate molecules in DRG axonal guidance. Our study revealed the fact that one of the candidate molecules may attract centrally projecting DRG fibers and that the other molecule may attract peripherally projecting DRG ones.
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Report
(4 results)
Research Products
(15 results)
