Study of the molecular mechanisms of brain sex differentiation of the SF-1 KO mouse
| Project/Area Number |
24590257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
IKEDA YAYOI 愛知学院大学, 歯学部, 教授 (00202903)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Masaaki 東京医科歯科大学, 医歯学総合研究科, 准教授 (20193211)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳の性分化 / 性ホルモン / ノックアウトマウス / エストロゲン / 脳の性差 |
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| Outline of Final Research Achievements |
To study the molecular mechanisms of brain sex differentiation, we analyzed the expression of several markers in the SF-1 knockout (KO) mice using immunohistochemistry. The localization and the positive cell number for these markers of SF-1 KO male and female mice were similar to those of WT females, indicating that the two brain regions of SF-1 KO male mice are feminized. The results support the idea that perinatal gonadal hormones are required for masculinization of the brain.
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Report
(4 results)
Research Products
(16 results)
