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Function of FOXO1 in the retinal vascular formation

Research Project

Project/Area Number 24590258
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionKagawa Prefectural College of Health Sciences

Principal Investigator

FURUYAMA Tatsuo  香川県立保健医療大学, 教養部, 教授 (20238702)

Co-Investigator(Kenkyū-buntansha) INAGAKI Shinobu  大阪大学, 大学院医学研究科, 教授 (90151571)
Research Collaborator FUKUMOTO Moe  
UNI Kazumasa  
KOUHARA Misaki  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords血管形成 / 網膜 / tip細胞 / リンパ管形成
Outline of Final Research Achievements

FOXO1 is a transcription factor known to be involved in vascular formation during embryonic development. We examined whether the deficiency of FOXO1 in the endothelial cells affected the vascular formation in the retina during postnatal development. In the FOXO1-deficient retina, the spread of vascular network from the center of the retina was significantly reduced, the branching points of blood vessels and the number of tip cells were significantly increased compared to the control. Although FOXO1 was expressed in all endothelial cells, it was dominantly localized in the cytosol of stalk cells and some of tip cells and in the nuclei of some of tip cells and the endothelial cells of a capillary vessel in the vascular plexus. The localization of FOXO1 to the cytosol in the tip cells was partially regulated through the phosphorylation by Akt. Taken together, it is suggested that FOXO1 may play a different role in between regions of vessels during vascular formation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2015 2013 2012

All Journal Article (1 results) Presentation (3 results)

  • [Journal Article] Analysis of Foxo1-regulated genes using Foxo1-deficient pancreatic β cells2012

    • Author(s)
      Miyazaki S, Minamida R, Furuyama T, Tashiro F, Yamato E, Inagaki S, Miyazaki J.
    • Journal Title

      Genes Cells

      Volume: 17 Pages: 758-767

    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of FoxO1 on angiogenesis in the retina2015

    • Author(s)
      Fukumoto Moe, Ueda Shinnosuke,Uni Kazumasa, Ueda Mizuha, Furuyama tatsuo, Inagaki Shinobu
    • Organizer
      第120回日本解剖学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Altered localization of Foxo1 in neuron by methamphetamine2015

    • Author(s)
      Yasunaga Masayuki, Moriguchi Daisuke, Kido Keisuke, Inagaki Shinobu, Furuyama Tatsuo
    • Organizer
      第120回日本解剖学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病マウス血管内皮細胞におけるFoxo1の機能2013

    • Author(s)
      宇仁和将、香原美咲、福本萌、植田進之助、古山達雄、稲垣忍
    • Organizer
      日本解剖学会
    • Place of Presentation
      高松
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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