| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
The virus entry has two types of the entry routes; one is a route from the binding-site of the virus on the plasma membrane, while the other is a moving on the plasma membrane from binding-site to entry site. We revealed that human coronavirus 229E uses the later route and that the virus needs the macro clustering of membrane domains. Here, we studied the movement of the cross-linked virus receptors by antibodies in order to clarify the mechanism of the virus movement on the plasma membrane. The results suggest that the macro clustering of membrane domains depends on the movement of the membrane-associated actin filaments.
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