The clustering mechanism and the driving force of the macro membrane domains
| Project/Area Number |
24590264
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fujita Health University |
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Principal Investigator |
NOMURA Ryuji 藤田保健衛生大学, 医学部, 講師 (20325161)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOMURA Atsushi 北海道医療大学, 心理科学部, 教授 (50340237)
KOGO Akiko 群馬大学, 医学系研究科, 助教 (20340242)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アクチンフィラメント / CD13 / 膜ドメイン / コロナウイルス / ラフト / アクチン / クラスタリング |
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| Outline of Final Research Achievements |
The virus entry has two types of the entry routes; one is a route from the binding-site of the virus on the plasma membrane, while the other is a moving on the plasma membrane from binding-site to entry site. We revealed that human coronavirus 229E uses the later route and that the virus needs the macro clustering of membrane domains. Here, we studied the movement of the cross-linked virus receptors by antibodies in order to clarify the mechanism of the virus movement on the plasma membrane. The results suggest that the macro clustering of membrane domains depends on the movement of the membrane-associated actin filaments.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Requirement of DLG1 for cardiovascular development and tissue elongation during cochlear, enteric, and skeletal development: possible role in convergent extension.2015
Author(s)
Akiko Iizuka-Kogo, Takao Senda, Tetsu Akiyama, Atsushi Shimomura, Ryuji Nomura, Yoshimi Hasegawa, Ken-ichi Yamamura, Hiroshi Kogo, Nobuhiko Sawai, and Toshiyuki Matsuzaki.
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Journal Title
Plos One
Volume: 10
Pages: 1-19
Related Report
Peer Reviewed / Open Access
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[Journal Article] Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia2014
Author(s)
Takanori Onouchi, Katsunori Kobayashi, Kazuyoshi Sakai, Atsushi Shimomura, Ron Smits, Chiho Sumi-Ichinose, Masafumi Kurosumi Keizo Takao, Ryuji Nomura, Akiko Iizuka-Kogo, Hidenori Suzuki,Kazunao Kondo, Tetsu Akiyama Tsuyoshi Miyakawa Riccardo Fodde and Takao Senda, Riccardo Fodde, Takao
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Journal Title
Molecular Brain
Volume: 7
Issue: 1
Pages: 21-21
DOI
Related Report
Peer Reviewed / Open Access
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