An Analysis of dynamic cardiac regulation during active state in mice
| Project/Area Number |
24590268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Akita University |
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Principal Investigator |
SHINICHI SATO 秋田大学, 医学(系)研究科(研究院), 非常勤講師 (10375305)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 精神的ストレス / ストレス反応 / 情動系 / 自律神経 / 心拍数 / 心房細動 / 睡眠 / 自由行動 / マウス / 循環調節 / 交感神経系 / 副交感神経系 / ストレス / 発汗応答 / ピエゾ素子 / 心電図 / 国際情報交換 / センサー / ピエゾ / 非拘束自由行動下 / 平板電極 / 国際情報交換（アメリカ） |
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| Outline of Final Research Achievements |
I have developed a flat-plate electrocardiogram/piezoelectric-element hybrid sensor for continuous electrocardiographic recording in freely-moving mice without the need for electrode-implantation surgery and made a patent application on the hybrid-sensor system (#2015-058838). As the sensor required the sweating (emotional sweating) on the soles of mice for the electrocardiographic recording, experiments were performed during under stress and during sleep, and there were several findings as follows: (1) Mice exhibit heartrate elevation with sweating on their soles as psychological-stress response when exposed to sounds or vibration and when being gazed at by an experimenter. (2) In contrast to humans, mice exhibit sweating on their soles during sleep. (3) The response of (1) becomes a more dynamic change in heart rate when conducted during sleep, and furthermore, mice exhibit an arrhythmia thought to be the atrial fibrillation.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] Slow and rapid heart rate change in mice/rats mediated by sympathetic-parasympathetic interaction in intrinsic cardiac ganglia2013
Author(s)
S SATO, J TOKUNAGA, T KANBAYASHI, Y SAGAWA, M SATO, N SAKAI, K ONO, T SHIMIZU, S NISHINO
Organizer
Neuroscience 2013
Place of Presentation
San Diego, CA, USA
Related Report
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[Book] 自律神経2013
Author(s)
佐藤 紳一
Total Pages
8
Publisher
日本自律神経学会
Related Report
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