| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Sperm chromosome forms highly condensed chromatin structure during spermatogenesis to send their information to next generation. We focus on a biological similarity between adenovirus infection cycle and spermatogenesis/fertilization. A histone chaperone, TAF-I, is not only able to remodel adenoviral chromatin structure, but also to make sperm chromatin decondensed in vitro. A series of experiments suggests that TAF-I is involved in cell growth during differentiation and development through its histone chaperone activity.
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