| Project/Area Number |
24590273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Yuko 浜松医科大学, 医学部, 准教授 (20345812)
SANO Hideto 浜松医科大学, 医学部, 助教 (80623842)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 凝固 / 線溶 / 血小板 / plasminogen / carboxylpeptidase / 血栓 |
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| Outline of Final Research Achievements |
Contribution of activated platelets on the initiation of coagulation cascade, fibrin formation as well as its lysis was analyzed. For the exposure of phosphatidylserine (PS) on activated platelets, integrin outside-in signals generated by platelet binding to a rigid fibrin network, and the resultant mechanical foci to stretch platelets through this binding, appeared to be essential. We also found that plasminogen binds to PS exposing platelets which then initiated fibrinolysis as starting points. This seems important to quickly dissolve generated excess amounts of thrombi in order to keep vascular patency. The accumulation of plasminogen in the center of micro-thrombuss, where platelets were exposing PS and fibrin was formed, was demonstrated from the early phase of thrombus formation. This suggests the physiological importance of coagulation-fibrinolysis cross-talk for normal hemostais.
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